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Patients with non-Hodgkin's lymphoma occasionally develop widespread invasion of peripheral nerves by tumor cells or neurolymphomatosis (NL). Clinically this usually results in asymmetrical, progressive, and painful polyneuropathy. Diagnosis rests on the identification of tumor cells in peripheral nerves. To avoid false-negative biopsy findings in patients with malignant lymphomatous infiltration of peripheral nerves it has been recommended to biopsy clinically involved nerves. We present two patients with histologically confirmed NL in whom sural the nerve biopsy finding was negative despite clinical and neurophysiological evidence of involvement of the sural nerve a. The clinical features of NL are reviewed. Some patients with neurolyphomatosis have only focal or proximal involvement of nerves, requiring the biopsy of an affected part of these nerves. Magnetic resonance imaging may be useful in identifying affected nerves.
M J van den Bent, and
H G de Bruin, and
G M Bos, and
G Brutel de la Rivière, and
P A Sillevis Smitt
January 2013,
Frontiers in neurology,
M J van den Bent, and
H G de Bruin, and
G M Bos, and
G Brutel de la Rivière, and
P A Sillevis Smitt
October 2000,
Journal of neurology, neurosurgery, and psychiatry,
M J van den Bent, and
H G de Bruin, and
G M Bos, and
G Brutel de la Rivière, and
P A Sillevis Smitt
November 1969,
The Medical journal of Australia,
M J van den Bent, and
H G de Bruin, and
G M Bos, and
G Brutel de la Rivière, and
P A Sillevis Smitt
July 1968,
American journal of surgery,
M J van den Bent, and
H G de Bruin, and
G M Bos, and
G Brutel de la Rivière, and
P A Sillevis Smitt
March 1973,
Journal of neurosurgery,
M J van den Bent, and
H G de Bruin, and
G M Bos, and
G Brutel de la Rivière, and
P A Sillevis Smitt
March 2006,
Journal of clinical neuromuscular disease,
M J van den Bent, and
H G de Bruin, and
G M Bos, and
G Brutel de la Rivière, and
P A Sillevis Smitt
February 2024,
Practical neurology,
M J van den Bent, and
H G de Bruin, and
G M Bos, and
G Brutel de la Rivière, and
P A Sillevis Smitt
July 2007,
Archives of neurology,
M J van den Bent, and
H G de Bruin, and
G M Bos, and
G Brutel de la Rivière, and
P A Sillevis Smitt
January 2007,
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons,
M J van den Bent, and
H G de Bruin, and
G M Bos, and
G Brutel de la Rivière, and
P A Sillevis Smitt
June 1988,
Acta neurologica Scandinavica,
