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The chromosome banding pattern was analyzed in bone-marrow cells and/or spleen cells of 10 patients in the blastic phase of chronic myeloid leukemia (CML). It was obvious from the karyotype analysis that the chromosome aberrations occurring addition to the Philadelphia chromosome (Ph1) were strictly non-random. An extra Ph1, trisomy 8 and/or trisomy for the long arm of chromosome 17 were observed in all cases. This consistent pattern of chromosome involvement in CML was confirmed in 57 cases from the literature studied with banding techniques. In 88% of the total number of cases with further changes at least one of the three main chromosomal aberrations was found ("major route" of karyotypic evolution).
F Mitelman, and
G Levan, and
P G Nilsson, and
L Brandt
January 1979,
Leukemia research,
F Mitelman, and
G Levan, and
P G Nilsson, and
L Brandt
February 1984,
Cancer genetics and cytogenetics,
F Mitelman, and
G Levan, and
P G Nilsson, and
L Brandt
January 2012,
Indian journal of human genetics,
F Mitelman, and
G Levan, and
P G Nilsson, and
L Brandt
September 1985,
Cancer genetics and cytogenetics,
F Mitelman, and
G Levan, and
P G Nilsson, and
L Brandt
December 1986,
Cancer genetics and cytogenetics,
F Mitelman, and
G Levan, and
P G Nilsson, and
L Brandt
December 1991,
Cancer genetics and cytogenetics,
F Mitelman, and
G Levan, and
P G Nilsson, and
L Brandt
July 1997,
British journal of haematology,
F Mitelman, and
G Levan, and
P G Nilsson, and
L Brandt
December 1985,
American journal of hematology,
F Mitelman, and
G Levan, and
P G Nilsson, and
L Brandt
January 1967,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
F Mitelman, and
G Levan, and
P G Nilsson, and
L Brandt
November 2005,
Cancer genetics and cytogenetics,
