BIOMAT Database Logo BIOMAT Database Logo

Reappraisal of Tc-99m DMSA scintigraphy for follow up in children with vesicoureteral reflux. 1999

E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
Department of Nuclear Medicine, Hokkaido University School of Medicine,Sapporo, Japan.

We reviewed Tc-99m DMSA scintigraphy in children with vesicoureteral reflux (VUR) in order to assess whether repeated Tc-99m DMSA scans are necessary for the follow up of these patients. Ninety-seven children who were followed up for more than one year (1-7.4 years, average 2.8 years) after the first DMSA scan were included in the study. Fifty-one patients had been diagnosed as primary VUR and 46 as secondary VUR. Age at the first examination ranged from 0 to 14 years (average 5.1 years). Planar images were taken 2 hours after injection. The % renal uptake per injected dose (%RU) was calculated from posterior images. Kidneys in 11 patients (11.3%) changed morphologically during the follow up. Of these, new photon deficient areas (PD) were detected in only 4 patients (4.1%). All of these 4 patients had neurogenic bladder and were managed with self-catheterization. Of the remaining 7 patients, cortical thinning progressed in 5 patients (5.2%) and PDs resolved in 3 patients (3.1%). In one of these 7 patients, PD resolved in one kidney and cortical thinning progressed in the contralateral kidney. Of 97 patients reviewed, % RU decreased more than 20% during the follow up in 6 patients (6.2%). All were diagnosed as secondary VUR due to neurogenic bladder. %RU decreased only in the contracted kidneys at the initial scan. Two of them underwent renal transplantation because of severe renal failure. In conclusion, new PD rarely developed and % RU decreased in only a few patients during the follow up of children with VUR. Repeated Tc-99m DMSA scintigraphy therefore seems to have little benefit in the follow up of children with VUR. It should be performed in selected patients with high risk of urinary tract infection or renal failure.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008297 Male Males
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D001750 Urinary Bladder, Neurogenic Dysfunction of the URINARY BLADDER due to disease of the central or peripheral nervous system pathways involved in the control of URINATION. This is often associated with SPINAL CORD DISEASES, but may also be caused by BRAIN DISEASES or PERIPHERAL NERVE DISEASES. Bladder Disorder, Neurogenic,Neurogenic Bladder,Bladder Neurogenesis,Bladder, Neurogenic,Neurogenic Bladder Disorder,Neurogenic Bladder, Atonic,Neurogenic Bladder, Spastic,Neurogenic Bladder, Uninhibited,Neurogenic Dysfunction of the Urinary Bladder,Neurogenic Urinary Bladder Disorder,Neurogenic Urinary Bladder, Atonic,Neurogenic Urinary Bladder, Spastic,Neurogenic Urinary Bladder, Uninhibited,Neuropathic Bladder,Urinary Bladder Disorder, Neurogenic,Urinary Bladder Neurogenesis,Urinary Bladder Neurogenic Dysfunction,Atonic Neurogenic Bladder,Neurogenesis, Bladder,Neurogenesis, Urinary Bladder,Neurogenic Bladder Disorders,Neurogenic Urinary Bladder,Spastic Neurogenic Bladder,Uninhibited Neurogenic Bladder
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
Surgical correction of vesicoureteral reflux: 5-year follow-up with 99Tcm-DMSA scintigraphy.
February 2001, Nuclear medicine communications,
E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
Acute Tc-99m DMSA scan for identifying dilating vesicoureteral reflux in children: a meta-analysis.
July 2011, Pediatrics,
E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
Follow-up of acute pyelonephritis in children by Tc-99m DMSA scintigraphy: quantitative and qualitative assessment.
May 2001, Clinical nuclear medicine,
E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
[Technetium 99m labeled dimercaptosuccinic acid (99m Tc-DMSA) scintigraphy in the diagnosis and follow-up of urinary infections in children].
May 1993, Archives francaises de pediatrie,
E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
Use of Tc-99m DMSA and Tc-99m DTPA in reflux.
May 1986, Seminars in urology,
E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
Megaureter visualization on Tc-99m DMSA scintigraphy.
July 2005, Annals of nuclear medicine,
E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
Tc-99m pentavalent DMSA scintigraphy in myelofibrosis detection.
December 2006, Clinical nuclear medicine,
E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
Renal artery stenosis diagnosed with Tc-99m DMSA scintigraphy.
January 1994, Clinical nuclear medicine,
E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
Distribution of renal parenchymal damage on 99m-Tc DMSA scintigraphy in vesico-ureteric reflux.
January 1990, Annales chirurgiae et gynaecologiae,
E Sukamoto, and K Itoh, and K Morita, and C Katoh, and K Nakada, and K Nonomura, and H Kakizaki, and T Koyanagi, and N Tamaki
Vesicoureteral Reflux Detected with (99m)Tc-DTPA Renal Scintigraphy during Evaluation of Renal Function.
March 2016, Open access Macedonian journal of medical sciences,
Copied contents to your clipboard!