Urinary fluoride excretion in small children following short-term fluoride supply with tablets or domestic salt. 1976

I Hellström, and Y Ericsson

Urinary fluoride (F) excretion has been studied in small children, with some comparisons with adults, following ingestion of F tablets or fluoridated salt (F-salt) containing 500 mg F/kg NaCl. 24-h urinary F in 7- to 8-year-old children in an institution and in 2- to 12-year-old children in families rapidly increased to average levels of about 0.85 and 0.55 parts/10(6), respectively, when the children had their meals spiced with F-salt. Children in families also showed significantly elevated urinary F excretion with two F-salted meals a day but not with one a day. After taking 0.5 mg F in the form of NaF tablets a group of children without previous F supply attained within 1 d a 24-h urinary F concentration which was about the same as that in children who had been taking caries-preventive tablet doses for years. The percentage of a single F dose excreted in the urine within 4 h after the ingestion of F tablets or an F-salted standard meal was about the same in preschool children and middle-aged adults. F quantities of the order 1.5-2 mg could be ingested by a child eating a meal comprising strongly F-salted dishes, and the urine could reach concentrations around 3 parts/10(6) F during the following 2-4 h. The results obtained support the concept that domestic salt containing about 500 parts/10(6) F is suitable for clinical testing on a larger scale under Swedish conditions. Calculations of F supplies to children aged 2 months-7 years with different diets and water and salt F contents are presented as diagrams.

UI MeSH Term Description Entries
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002940 Circadian Rhythm The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli. Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D005459 Fluorides Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices. Fluoride
D005503 Food Additives Substances used in the processing or storage of foods or animal feed including ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS; EXCIPIENTS and other similarly used substances. Many of the same substances are used as PHARMACEUTIC AIDS. Additive, Food,Additives, Food,Food Additive
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012965 Sodium Chloride A ubiquitous sodium salt that is commonly used to season food. Sodium Chloride, (22)Na,Sodium Chloride, (24)NaCl
D013607 Tablets Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed) Tablet
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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