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The p53 tumor suppressor protein is a critical regulator of cell cycle progression and apoptosis following exposure of cells to DNA damaging agents such as ionizing radiation or anticancer drugs. An important group of anticancer drugs, including compounds such as etoposide and doxorubicin (Adriamycin), interacts with DNA topoisomerase II (topo II), causing the accumulation of enzyme-DNA adducts that ultimately lead to double-strand breaks and cell death via apoptosis. Human topo IIbeta has previously been shown to interact with p53, and we have extended this analysis to show that both topo IIalpha and IIbeta interact with p53 in vivo and in vitro. Furthermore, we show that the regulatory C-terminal basic region of p53 (residues 364-393) is necessary and sufficient for interaction with DNA topo II.
I G Cowell, and
A L Okorokov, and
S A Cutts, and
K Padget, and
M Bell, and
J Milner, and
C A Austin
January 2007,
Nucleic acids research,
I G Cowell, and
A L Okorokov, and
S A Cutts, and
K Padget, and
M Bell, and
J Milner, and
C A Austin
January 2000,
Brain tumor pathology,
I G Cowell, and
A L Okorokov, and
S A Cutts, and
K Padget, and
M Bell, and
J Milner, and
C A Austin
December 1998,
Cancer research,
I G Cowell, and
A L Okorokov, and
S A Cutts, and
K Padget, and
M Bell, and
J Milner, and
C A Austin
September 2001,
British journal of cancer,
I G Cowell, and
A L Okorokov, and
S A Cutts, and
K Padget, and
M Bell, and
J Milner, and
C A Austin
December 1998,
The Journal of biological chemistry,
I G Cowell, and
A L Okorokov, and
S A Cutts, and
K Padget, and
M Bell, and
J Milner, and
C A Austin
November 1996,
Nucleic acids research,
I G Cowell, and
A L Okorokov, and
S A Cutts, and
K Padget, and
M Bell, and
J Milner, and
C A Austin
March 1999,
Biochimica et biophysica acta,
I G Cowell, and
A L Okorokov, and
S A Cutts, and
K Padget, and
M Bell, and
J Milner, and
C A Austin
July 1999,
Anti-cancer drugs,
I G Cowell, and
A L Okorokov, and
S A Cutts, and
K Padget, and
M Bell, and
J Milner, and
C A Austin
January 2000,
Cell biochemistry and biophysics,
I G Cowell, and
A L Okorokov, and
S A Cutts, and
K Padget, and
M Bell, and
J Milner, and
C A Austin
August 2005,
Biochemistry,
