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Iduronate sulfatase, the enzyme deficient in Hunter syndrome, can be readily measured in individual hair roots. Samples from Hunter syndrome hemizygotes had activities at or near the limits of detection. Samples from two mothers of Hunter syndrome patients, one an obligate heterozygote, had lower average iduronate sulfatase activity than the normal mean, and a significant number of hair roots had activity in the pathognomic range. A third mother showed a normal distribution of enzyme activity, and no hair roots were in the range of those from an affected individual. These results are similar to studies on the distribution of other X-linked enzymes in individual hair root samples from heterozygotes. This suggests that hair root iduronate sulfatase assessment is useful in the detection of Hunter syndrome carrier status, but further refinement of the test system is necessary.
T Yutaka, and
A L Fluharty, and
R L Stevens, and
H Kihara
January 1979,
American journal of human genetics,
T Yutaka, and
A L Fluharty, and
R L Stevens, and
H Kihara
October 1974,
Carbohydrate research,
T Yutaka, and
A L Fluharty, and
R L Stevens, and
H Kihara
May 1998,
Clinical genetics,
T Yutaka, and
A L Fluharty, and
R L Stevens, and
H Kihara
June 2017,
Nature communications,
T Yutaka, and
A L Fluharty, and
R L Stevens, and
H Kihara
December 2008,
Journal of inherited metabolic disease,
T Yutaka, and
A L Fluharty, and
R L Stevens, and
H Kihara
March 1987,
Human genetics,
T Yutaka, and
A L Fluharty, and
R L Stevens, and
H Kihara
November 1990,
Proceedings of the National Academy of Sciences of the United States of America,
T Yutaka, and
A L Fluharty, and
R L Stevens, and
H Kihara
August 1984,
The New England journal of medicine,
T Yutaka, and
A L Fluharty, and
R L Stevens, and
H Kihara
November 1992,
Human genetics,
T Yutaka, and
A L Fluharty, and
R L Stevens, and
H Kihara
October 2013,
BMC medical genomics,
