Aldosterone regulates Na,K-ATPase and increases lung edema clearance in rats. 2000

W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
Pulmonary and Critical Care Medicine Division, Northwestern University Medical School, Chicago, IL 60611, USA.

Aldosterone increases the Na,K-ATPase function in renal cells involved in active Na(+) transport. Because the alveolar type 2 (AT2) cells participate in active Na(+) transport, we studied whether aldosterone regulates the Na,K-ATPase in rat AT2 cells and whether aldosterone delivered by aerosols to spontaneously breathing rats affects edema clearance in a model of isolated-perfused lungs. The AT2 cells treated with aldosterone had increased Na,K-ATPase beta1-subunit mRNA and protein, which was associated with a 4-fold increase in the Na,K-ATPase hydrolytic activity and the ouabain-sensitive (86)Rb(+) uptake. In physiologic experiments, 24 h after aldosterone was delivered by aerosols to the rat air spaces, the active Na(+) transport and lung edema clearance increased by approximately 53% as compared with control rats and rats in which saline aerosols were delivered. The data suggest that increased active Na(+) transport and lung edema clearance induced by aldosterone is probably due to Na,K-ATPase regulation in alveolar epithelial cells. Conceivably, aldosterone may be used as a strategy to increase lung edema clearance.

UI MeSH Term Description Entries
D008297 Male Males
D010477 Perfusion Treatment process involving the injection of fluid into an organ or tissue. Perfusions
D011650 Pulmonary Alveoli Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place. Alveoli, Pulmonary,Alveolus, Pulmonary,Pulmonary Alveolus
D011654 Pulmonary Edema Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening. Wet Lung,Edema, Pulmonary,Edemas, Pulmonary,Pulmonary Edemas,Lung, Wet,Lungs, Wet,Wet Lungs
D000254 Sodium-Potassium-Exchanging ATPase An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients. ATPase, Sodium, Potassium,Adenosinetriphosphatase, Sodium, Potassium,Na(+)-K(+)-Exchanging ATPase,Na(+)-K(+)-Transporting ATPase,Potassium Pump,Sodium Pump,Sodium, Potassium ATPase,Sodium, Potassium Adenosinetriphosphatase,Sodium-Potassium Pump,Adenosine Triphosphatase, Sodium, Potassium,Na(+) K(+)-Transporting ATPase,Sodium, Potassium Adenosine Triphosphatase,ATPase Sodium, Potassium,ATPase, Sodium-Potassium-Exchanging,Adenosinetriphosphatase Sodium, Potassium,Pump, Potassium,Pump, Sodium,Pump, Sodium-Potassium,Sodium Potassium Exchanging ATPase,Sodium Potassium Pump
D000450 Aldosterone A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. Aldosterone, (+-)-Isomer,Aldosterone, (11 beta,17 alpha)-Isomer
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012964 Sodium A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. Sodium Ion Level,Sodium-23,Ion Level, Sodium,Level, Sodium Ion,Sodium 23
D015633 Extravascular Lung Water Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space. Lung Water, Extravascular,Extra Vascular Lung Water,Lung Water, Extra Vascular,Water, Extravascular Lung
D015971 Gene Expression Regulation, Enzymologic Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis. Enzymologic Gene Expression Regulation,Regulation of Gene Expression, Enzymologic,Regulation, Gene Expression, Enzymologic

Related Publications

W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
November 2002, Journal of applied physiology (Bethesda, Md. : 1985),
W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
July 1999, Chest,
W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
December 2003, American journal of respiratory and critical care medicine,
W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
October 1995, American journal of respiratory and critical care medicine,
W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
February 2005, American journal of respiratory and critical care medicine,
W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
November 1997, Annals of the New York Academy of Sciences,
W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
April 1997, Journal of applied physiology (Bethesda, Md. : 1985),
W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
January 1992, Seminars in nephrology,
W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
February 2004, American journal of respiratory and critical care medicine,
W G Olivera, and D E Ciccolella, and N Barquin, and K M Ridge, and D H Rutschman, and D B Yeates, and J I Sznajder
October 2005, American journal of respiratory cell and molecular biology,
Copied contents to your clipboard!