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Age-specific effects of noradrenergic alpha-2 agonist clonidine on the development of amygdaloid kindling in developing rats. 2000
S Yoshioka, and
H Mitani, and
K Maeda, and
S Takeo, and
K Matsuda, and
S Katayama, and
R Mizukawa, and
R Kawahara
Department of Neuropsychiatry, Faculty of Medicine, Tottori University, 86, Nishi-machi, Yonago, Japan. shiyoshi@grape.med.tottori-u.ac.jp
The effects of clonidine on the development of amygdaloid kindling were studied in rats of various ages (14, 21, 28 and 70 postnatal days). Administration of clonidine (0.2, 0.5 mg/kg i.p.) caused a significant retardation of kindling development in the 28-day-old rats as well as in the adult rats, whereas, in the 14-day-old rats, the development of kindling was significantly facilitated by clonidine. No significant effect of clonidine was observed in the 21-day-old rats. These results indicate that in rats the effects of clonidine on the development of amygdaloid kindling vary during development.
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