Biomaterial Database

Acute cardiovascular responses to radioprotective mixture of cystamine and 5-methoxytryptamine in rats. 1975

P Kuna

I.p. administration of radioprotective mixture of cystamine (18 mg base/kg) and 5-methoxytryptamine (3 mg base/kg) to anesthetized rats induced the depression of hemodynamics. Decrease of cardiac output, hypotension, bradycardia, increase in peripheral vascular resistance, the escape of plasma from the vascular stream, pronounced diminution of blood flow in the spleen and other tissues were determined. Pharmacological properties of the protective can contribute to its radioprotective efficiency in the whole mammalian organism.

UI	MeSH Term	Description	Entries
D008735	5-Methoxytryptamine	Serotonin derivative proposed as potentiator for hypnotics and sedatives.	Meksamine,Methoxytryptamine,Mexamine,5 Methoxytryptamine
D003538	Cystamine	A radiation-protective agent that interferes with sulfhydryl enzymes. It may also protect against carbon tetrachloride liver damage.	Cystineamine,Decarboxycystine,Diaminodiethyldisulfide,2,2'-Dithiobisethanamine,Cystamine Calcium Salt,Cystamine Diacetate,Cystamine Dihydrobromide,Cystamine Dihydrochloride,Cystamine Hydrobromide,Cystamine Hydrochloride,Cystamine Sulfate,Cystamine Sulfate (1:1),Cysteinamine Disulfide,Cystinamin,2,2' Dithiobisethanamine,Calcium Salt, Cystamine,Diacetate, Cystamine,Dihydrobromide, Cystamine,Dihydrochloride, Cystamine,Disulfide, Cysteinamine,Hydrobromide, Cystamine,Hydrochloride, Cystamine,Sulfate, Cystamine
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D005260	Female		Females
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014363	Tryptamines	Decarboxylated monoamine derivatives of TRYPTOPHAN.	Indolylethylamines,Triptan,Triptans
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus