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Local SIgA response following administration of a novel intranasal inactivated influenza virus vaccine in community residing elderly. 2000
M Muszkat, and
G Friedman, and
M H Schein, and
P Naveh, and
E Greenbaum, and
M Schlesinger, and
Z Zakay-Rones, and
A B Yehuda
Geriatric Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Community-residing elderly were immunized twice intranasally three weeks apart with a new inactivated whole influenza vaccine. A control group was immunized intramuscularly with conventional influenza vaccine. Local antibody response was detected in about 50% of intranasally immunized subjects compared to about 20% of intramuscularly immunized subjects, to the three viral strains. Increasing the incidence of elevated IgA response may prevent influenza at its early stages thus reducing complications in the elderly.
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