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This study investigates the influence of haematocrit, fibrinogen concentration and fibrinogen availability (amount of fibrinogen per red blood cell) on erythrocyte sedimentation. The Westergren technique was applied to blood samples from 36 subjects and to their blood manipulated to haematocrits of 10, 20, 30 and 40%. Readings were taken every 10 minutes for 300 minutes. Previous studies indicate that erythrocyte sedimentation occurs in three phases. In this study, we show that haematocrit has little influence on either the rate of fall of particles in the first phase (m1) or the duration of the first phase. This is also true for fibrinogen availability and for fibrinogen concentration at low haematocrits. At high haematocrits m1 increases with fibrinogen concentration. The rate of fall of rouleaux during phase 2 (m2) and ESR60 both decrease exponentially with haematocrit and increase linearly with fibrinogen concentration. While m2 is more closely correlated to fibrinogen availability than to fibrinogen concentration or to haematocrit, this is not the case for ESR60. Thus haematocrit, fibrinogen concentration and fibrinogen availability are more important to the velocity of sedimentation in the second phase than to the sedimenting velocity during phase 1 or to the duration of phase 1.
L Holley, and
N Woodland, and
W T Hung, and
K Cordatos, and
A Reuben
January 1957,
Polskie Archiwum Medycyny Wewnetrznej,
L Holley, and
N Woodland, and
W T Hung, and
K Cordatos, and
A Reuben
January 1973,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
L Holley, and
N Woodland, and
W T Hung, and
K Cordatos, and
A Reuben
August 1979,
Thrombosis and haemostasis,
L Holley, and
N Woodland, and
W T Hung, and
K Cordatos, and
A Reuben
August 1978,
Casopis lekaru ceskych,
L Holley, and
N Woodland, and
W T Hung, and
K Cordatos, and
A Reuben
February 1951,
Deutsche medizinische Wochenschrift (1946),
L Holley, and
N Woodland, and
W T Hung, and
K Cordatos, and
A Reuben
March 2014,
Anti-inflammatory & anti-allergy agents in medicinal chemistry,
L Holley, and
N Woodland, and
W T Hung, and
K Cordatos, and
A Reuben
January 1979,
The Journal of rheumatology,
L Holley, and
N Woodland, and
W T Hung, and
K Cordatos, and
A Reuben
January 1957,
Acta medica Scandinavica,
L Holley, and
N Woodland, and
W T Hung, and
K Cordatos, and
A Reuben
November 1983,
Scandinavian journal of haematology,
L Holley, and
N Woodland, and
W T Hung, and
K Cordatos, and
A Reuben
January 1947,
Annales de biologie clinique,
