BIOMAT Database Logo BIOMAT Database Logo

Contribution of adverse drug reactions to hospital admission of older patients. 2000

C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
Department of Geriatric Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands. c.mannesse@worldonline.nl

OBJECTIVE To describe the severity of adverse drug reactions as a factor in hospital admission of older patients, and to identify risk indicators for severe adverse drug reactions in these patients. METHODS Observational cross-sectional study. METHODS Five wards in a university hospital in The Netherlands. METHODS Patients aged 70 and over admitted to general medical wards. METHODS Use of statistical comparison and Kramer's algorithm. RESULTS A severe adverse drug reaction was present in 25 (24%) of 106 patients. Thirteen patients (12%; 95% confidence interval 6.1-18.6%) were admitted probably because of an adverse drug reaction. Risk indicators for a severe adverse drug reaction were a fall before admission (odds ratio 51.3, P = 0.006), gastrointestinal bleeding or haematuria (odds ratio 19.8, P < 0.001) and the use of three or more drugs (odds ratio 9.8, P = 0.04). CONCLUSIONS Adverse drug reactions are an important cause of hospital admissions in older people. A fall before admission may indicate a severe adverse drug reaction.

UI MeSH Term Description Entries
D008297 Male Males
D009426 Netherlands Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, and Sint Maarten, formerly included in the NETHERLANDS ANTILLES. Holland,Kingdom of the Netherlands
D010343 Patient Admission The process of accepting patients. The concept includes patients accepted for medical and nursing care in a hospital or other health care institution. Voluntary Admission,Admission, Patient,Admission, Voluntary,Admissions, Patient,Admissions, Voluntary,Patient Admissions,Voluntary Admissions
D003430 Cross-Sectional Studies Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time. Disease Frequency Surveys,Prevalence Studies,Analysis, Cross-Sectional,Cross Sectional Analysis,Cross-Sectional Survey,Surveys, Disease Frequency,Analyses, Cross Sectional,Analyses, Cross-Sectional,Analysis, Cross Sectional,Cross Sectional Analyses,Cross Sectional Studies,Cross Sectional Survey,Cross-Sectional Analyses,Cross-Sectional Analysis,Cross-Sectional Study,Cross-Sectional Surveys,Disease Frequency Survey,Prevalence Study,Studies, Cross-Sectional,Studies, Prevalence,Study, Cross-Sectional,Study, Prevalence,Survey, Cross-Sectional,Survey, Disease Frequency,Surveys, Cross-Sectional
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D005260 Female Females
D006785 Hospitals, University Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research. University Hospitals
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000058 Accidental Falls Falls due to slipping or tripping which may result in injury. Falls, Accidental,Falling,Falls,Slip and Fall,Accidental Fall,Fall and Slip,Fall, Accidental
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
Adverse drug reactions and hospital admission of older patients.
November 2000, Age and ageing,
C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
[Hospital admission due to adverse drug reactions].
August 1976, Harefuah,
C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
[Drug adverse reactions leading to hospital admission].
January 2002, Revista da Associacao Medica Brasileira (1992),
C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
Adverse drug reactions leading to hospital admission.
January 1991, Drug safety,
C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
Adverse drug reactions related to hospital admission in Slovak elderly patients.
January 2009, Archives of gerontology and geriatrics,
C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
Adverse drug reactions which provoke hospital admission.
January 2011, Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria,
C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
Adverse drug reactions resulting in hospital admission.
December 1994, International journal of clinical pharmacology and therapeutics,
C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
Adverse drug reactions causing admission to a paediatric hospital.
January 2012, PloS one,
C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
Adverse drug reactions in children leading to hospital admission.
July 1988, Pediatrics,
C K Mannesse, and F H Derkx, and M A de Ridder, and A J Man in 't Veld, and T J van der Cammen
Adverse drug reactions as cause of admission to hospital: definition of adverse drug reactions needs to include overdose.
August 2004, BMJ (Clinical research ed.),
Copied contents to your clipboard!