BIOMAT Database Logo BIOMAT Database Logo

Age-related differences in the secretion of calcitonin in male rats. 2000

C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Department of Physiology, School of Life Science, National Yang-Ming University, Taipei, Taiwan, Republic of China.

The mechanism of hypercalcitoninemia associated with aging was investigated in male rats. To mimic some of the hormonal changes with aging, orchidectomized (Orch) and hyperprolactinemic rats were used to mimic the physiological status of aging. Orch and haloperidol-induced hyperprolactinemic rats aged 3, 8, and 17 months were infused with CaCl2 and then bled from a jugular catheter following the CaCl2 challenge. Rat thyroid gland was incubated with Locke's medium at 37 degrees C for 30 minutes. Compared with 8- and 3-month-old rats, 17-month-old rats exhibited the lowest levels of plasma testosterone and the highest levels of plasma prolactin (PRL) and calcitonin (CT). The release of CT in the thyroid glands in vitro was highest in 17-month-old rats. Orchidectomy decreased rat plasma CT and thyroid CT release in vitro. Hyperprolactinemic rats had higher levels of plasma PRL and CT compared with control animals. The release of thyroid CT in vitro was greater in hyperprolactinemic rats. These results suggest that the hypersecretion of CT in 17-month-old rats may be due in part to hyperprolactinemia.

UI MeSH Term Description Entries
D008297 Male Males
D009919 Orchiectomy The surgical removal of one or both testicles. Castration, Male,Orchidectomy,Castrations, Male,Male Castration,Male Castrations,Orchidectomies,Orchiectomies
D011388 Prolactin A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate. Lactogenic Hormone, Pituitary,Mammotropic Hormone, Pituitary,Mammotropin,PRL (Prolactin),Hormone, Pituitary Lactogenic,Hormone, Pituitary Mammotropic,Pituitary Lactogenic Hormone,Pituitary Mammotropic Hormone
D011863 Radioimmunoassay Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation. Radioimmunoassays
D002116 Calcitonin A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults. Thyrocalcitonin,Calcitonin(1-32),Calcitrin,Ciba 47175-BA,Eel Calcitonin,Calcitonin, Eel,Ciba 47175 BA,Ciba 47175BA
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002122 Calcium Chloride A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning. Calcium Chloride Dihydrate,Calcium Chloride, Anhydrous
D006220 Haloperidol A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) Haldol
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Age-related differences in corticosterone secretion in female rats.
April 1999, Metabolism: clinical and experimental,
C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Age-related changes of calcitonin secretion in females.
March 1980, The Journal of clinical endocrinology and metabolism,
C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Age-Related Changes in Calcitonin-Producing Thyroid C-Cells of Male Wistar Rats.
May 2022, Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada,
C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Age-related differences in the hypocalcemic effect of calcitonin and calcium excretion in female rats.
January 1991, The Chinese journal of physiology,
C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Stimulation of calcitonin secretion by beta-calcitonin gene related peptide in rats.
January 1990, Endocrinologie,
C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Age-related differences in cytokine secretion.
January 1994, Gerontology,
C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Age-related differences in basal and calcium-stimulated plasma calcitonin levels in female rats.
May 1992, The American journal of physiology,
C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Age-related differences in gastric acid secretion and response of gastric inhibitory polypeptide after oral glucose in male rats.
January 1993, The Chinese journal of physiology,
C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Age-related differences in NMDA receptor subunits of prenatally methamphetamine-exposed male rats.
November 2014, Neurochemical research,
C C Lu, and S C Tsai, and E J Chien, and C L Tsai, and P S Wang
Age-related differences in Δ⁹-tetrahydrocannabinol-induced antinociception in female and male rats.
August 2019, Experimental and clinical psychopharmacology,
Copied contents to your clipboard!