-transparent.png){kind=logo}
BACKGROUND Previous uncontrolled reports have suggested that HIV-seropositive persons develop an accelerated form of emphysema. OBJECTIVE To characterize the risk for emphysema in a stable HIV-seropositive outpatient population. METHODS Controlled, cross-sectional analysis. METHODS Midwestern urban community. METHODS HIV-seropositive persons (n = 114) without AIDS-related pulmonary complications and HIV-seronegative controls (n = 44), matched for age and smoking history. METHODS Measurement of pulmonary function, bronchoalveolar lavage, and high-resolution computed tomography of the chest. RESULTS The incidence of emphysema was 15% (17 of 114) in the HIV-seropositive group compared with 2% (1 of 44) in the HIV-seronegative group (P = 0.025). The incidence of emphysema in participants with a smoking history of 12 pack-years or greater was 37% (14 of 38 persons) in the HIV-seropositive group compared with 0% (0 of 14 persons) in the HIV-seronegative group (P = 0.011). The percentage of cytotoxic lymphocytes in lavage fluid was much higher in HIV-seropositive smokers with emphysema. CONCLUSIONS Infection with HIV accelerates the onset of smoking-induced emphysema. The results of this study support the emerging concept that cytotoxic lymphocytes may have an important role in emphysema pathogenesis.
P T Diaz, and
M A King, and
E R Pacht, and
M D Wewers, and
J E Gadek, and
H N Nagaraja, and
J Drake, and
T L Clanton
February 2015,
Respiratory care,
P T Diaz, and
M A King, and
E R Pacht, and
M D Wewers, and
J E Gadek, and
H N Nagaraja, and
J Drake, and
T L Clanton
May 2002,
Thorax,
P T Diaz, and
M A King, and
E R Pacht, and
M D Wewers, and
J E Gadek, and
H N Nagaraja, and
J Drake, and
T L Clanton
December 2013,
American journal of physiology. Lung cellular and molecular physiology,
P T Diaz, and
M A King, and
E R Pacht, and
M D Wewers, and
J E Gadek, and
H N Nagaraja, and
J Drake, and
T L Clanton
January 2017,
Autopsy & case reports,
P T Diaz, and
M A King, and
E R Pacht, and
M D Wewers, and
J E Gadek, and
H N Nagaraja, and
J Drake, and
T L Clanton
June 1991,
The American review of respiratory disease,
P T Diaz, and
M A King, and
E R Pacht, and
M D Wewers, and
J E Gadek, and
H N Nagaraja, and
J Drake, and
T L Clanton
June 1992,
Sangre,
P T Diaz, and
M A King, and
E R Pacht, and
M D Wewers, and
J E Gadek, and
H N Nagaraja, and
J Drake, and
T L Clanton
October 2008,
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia,
P T Diaz, and
M A King, and
E R Pacht, and
M D Wewers, and
J E Gadek, and
H N Nagaraja, and
J Drake, and
T L Clanton
January 1991,
Annals of the New York Academy of Sciences,
P T Diaz, and
M A King, and
E R Pacht, and
M D Wewers, and
J E Gadek, and
H N Nagaraja, and
J Drake, and
T L Clanton
April 1965,
Virginia medical monthly,
P T Diaz, and
M A King, and
E R Pacht, and
M D Wewers, and
J E Gadek, and
H N Nagaraja, and
J Drake, and
T L Clanton
August 1956,
Annals of internal medicine,
