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The effects of renal failure on the pharmacokinetics of cyclosporine were investigated after intravenous, 30 mg/kg, and oral, 100 mg/kg, administration of the drug using a rat model of uranyl nitrate-induced acute renal failure (U-ARF). After intravenous administration to rats with U-ARF, the volume of distribution at steady state (1.97 vs. 2.56 l/kg) was significantly smaller, and the area under the blood concentration-time curve (348 vs. 296 microg h/ml) tended to be greater and total body clearance (0.0851 vs. 0. 102 l/h per kg) tended to be slower than those in control rats. After oral administration, the pharmacokinetic parameters were not significantly different between the control rats and rats with U-ARF, suggesting that U-ARF did not considerably affect the pharmacokinetics of cyclosporine after oral administration.
Y H Lee, and
K H Park, and
Y S Ku
April 2004,
Biopharmaceutics & drug disposition,
Y H Lee, and
K H Park, and
Y S Ku
January 2000,
Research communications in molecular pathology and pharmacology,
Y H Lee, and
K H Park, and
Y S Ku
October 1998,
Research communications in molecular pathology and pharmacology,
Y H Lee, and
K H Park, and
Y S Ku
December 1998,
Research communications in molecular pathology and pharmacology,
Y H Lee, and
K H Park, and
Y S Ku
February 1996,
Research communications in molecular pathology and pharmacology,
Y H Lee, and
K H Park, and
Y S Ku
October 2006,
Biopharmaceutics & drug disposition,
Y H Lee, and
K H Park, and
Y S Ku
May 1998,
Antimicrobial agents and chemotherapy,
Y H Lee, and
K H Park, and
Y S Ku
October 1999,
The Journal of pharmacy and pharmacology,
Y H Lee, and
K H Park, and
Y S Ku
January 2002,
Research communications in molecular pathology and pharmacology,
Y H Lee, and
K H Park, and
Y S Ku
April 1996,
Biopharmaceutics & drug disposition,
