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Buckminsterfullerenols were recently investigated for their protective properties in different models of acute and chronic neurodegeneration. We tested C3-fullero-tris-methanodicarboxylic acid in our in vitro model of apoptotic neuronal death, which consists of shifting the culture K+ concentration from 25 to 5 mM for rat cerebellar granule cells. The impairment of mitochondrial respiratory function as well as chromatin derangement and fragmentation of DNA in apoptotic oligonucleosomes that occur in these conditions were protected by this compound in a concentration-dependent way. To assess whether antioxidant activity could account for the rescue of cerebellar granule cells from apoptosis, we tested the fullerene derivative under FeSO4-induced oxidative stress and found significant protection. Thus, we visualized membrane and cytoplasmic peroxides and reactive oxygen species and found a significant reduction of the species after 24 h in 5 mM K+ with the fullerene derivative. Such evidence suggests that this compound exerts a protective role in cerebellar granule cell apoptosis, likely reducing the oxidative stress.
M Bisaglia, and
B Natalini, and
R Pellicciari, and
E Straface, and
W Malorni, and
D Monti, and
C Franceschi, and
G Schettini
January 1998,
Neuroscience letters,
M Bisaglia, and
B Natalini, and
R Pellicciari, and
E Straface, and
W Malorni, and
D Monti, and
C Franceschi, and
G Schettini
December 1998,
Annals of the New York Academy of Sciences,
M Bisaglia, and
B Natalini, and
R Pellicciari, and
E Straface, and
W Malorni, and
D Monti, and
C Franceschi, and
G Schettini
February 1999,
Journal of neuroscience research,
M Bisaglia, and
B Natalini, and
R Pellicciari, and
E Straface, and
W Malorni, and
D Monti, and
C Franceschi, and
G Schettini
August 2001,
Naunyn-Schmiedeberg's archives of pharmacology,
M Bisaglia, and
B Natalini, and
R Pellicciari, and
E Straface, and
W Malorni, and
D Monti, and
C Franceschi, and
G Schettini
October 2007,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
M Bisaglia, and
B Natalini, and
R Pellicciari, and
E Straface, and
W Malorni, and
D Monti, and
C Franceschi, and
G Schettini
May 2002,
The European journal of neuroscience,
M Bisaglia, and
B Natalini, and
R Pellicciari, and
E Straface, and
W Malorni, and
D Monti, and
C Franceschi, and
G Schettini
November 2002,
Neurochemical research,
M Bisaglia, and
B Natalini, and
R Pellicciari, and
E Straface, and
W Malorni, and
D Monti, and
C Franceschi, and
G Schettini
January 2000,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
M Bisaglia, and
B Natalini, and
R Pellicciari, and
E Straface, and
W Malorni, and
D Monti, and
C Franceschi, and
G Schettini
November 2002,
The Journal of biological chemistry,
M Bisaglia, and
B Natalini, and
R Pellicciari, and
E Straface, and
W Malorni, and
D Monti, and
C Franceschi, and
G Schettini
July 1998,
The Journal of pharmacology and experimental therapeutics,
