BIOMAT Database Logo BIOMAT Database Logo

Eukaryotic DNA polymerases, a growing family. 2000

U Hübscher, and H P Nasheuer, and J E Syväoja
Institute of Veterinary Biochemistry, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. hubscher@vetbio.unizh.ch

In eukaryotic cells, DNA polymerases are required to maintain the integrity of the genome during processes, such as DNA replication, various DNA repair events, translesion DNA synthesis, DNA recombination, and also in regulatory events, such as cell cycle control and DNA damage checkpoint function. In the last two years, the number of known DNA polymerases has increased to at least nine (called alpha, beta, gamma, delta, epsilon, zeta, eta, t and iota), and yeast Saccharomyces cerevisiae contains REV1 deoxycytidyl transferase.

UI MeSH Term Description Entries
D009713 Nucleotidyltransferases A class of enzymes that transfers nucleotidyl residues. EC 2.7.7. Nucleotidyltransferase
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D004258 DNA Polymerase III A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II. DNA Polymerase delta,DNA-Dependent DNA Polymerase III,DNA Pol III,DNA Dependent DNA Polymerase III,Polymerase III, DNA,Polymerase delta, DNA
D004259 DNA-Directed DNA Polymerase DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair. DNA Polymerase,DNA Polymerases,DNA-Dependent DNA Polymerases,DNA Polymerase N3,DNA Dependent DNA Polymerases,DNA Directed DNA Polymerase,DNA Polymerase, DNA-Directed,DNA Polymerases, DNA-Dependent,Polymerase N3, DNA,Polymerase, DNA,Polymerase, DNA-Directed DNA,Polymerases, DNA,Polymerases, DNA-Dependent DNA
D005057 Eukaryotic Cells Cells of the higher organisms, containing a true nucleus bounded by a nuclear membrane. Cell, Eukaryotic,Cells, Eukaryotic,Eukaryotic Cell
D005656 Fungal Proteins Proteins found in any species of fungus. Fungal Gene Products,Fungal Gene Proteins,Fungal Peptides,Gene Products, Fungal,Yeast Proteins,Gene Proteins, Fungal,Peptides, Fungal,Proteins, Fungal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000094769 DNA Polymerase iota A highly error-prone DNA polymerase. It is a member of the Y-family of DNA polymerases that are DNA DAMAGE tolerant and involved in TRANSLESION DNA SYNTHESIS. DNA polymerase iota is an orthologue of yeast Rad30. Its replication fidelity is template dependent and favors Hoogsteen base-pairing at its active site. POL iota,POLiota,RAD30B
D000097462 DNA Polymerase theta A specialized DNA polymerase that in humans is encoded by the POLQ gene. It is involved in DNA repair pathways, including DNA END-JOINING REPAIR and RECOMBINATIONAL DNA REPAIR. DNA Polymerase POLQ,POLQ, DNA Polymerase,Polymerase POLQ, DNA,Polymerase theta, DNA,theta, DNA Polymerase
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

U Hübscher, and H P Nasheuer, and J E Syväoja
Variations on a theme: eukaryotic Y-family DNA polymerases.
May 2010, Biochimica et biophysica acta,
U Hübscher, and H P Nasheuer, and J E Syväoja
[Eukaryotic DNA polymerases].
January 2005, Postepy biochemii,
U Hübscher, and H P Nasheuer, and J E Syväoja
Eukaryotic DNA polymerases.
December 2018, Current opinion in structural biology,
U Hübscher, and H P Nasheuer, and J E Syväoja
Eukaryotic DNA polymerases.
January 1991, Annual review of biochemistry,
U Hübscher, and H P Nasheuer, and J E Syväoja
Eukaryotic DNA polymerases.
January 1977, Annual review of biochemistry,
U Hübscher, and H P Nasheuer, and J E Syväoja
Eukaryotic DNA polymerases.
January 2002, Annual review of biochemistry,
U Hübscher, and H P Nasheuer, and J E Syväoja
Nomenclature of eukaryotic DNA polymerases.
October 1975, Science (New York, N.Y.),
U Hübscher, and H P Nasheuer, and J E Syväoja
Nomenclature of eukaryotic DNA polymerases.
November 1975, European journal of biochemistry,
U Hübscher, and H P Nasheuer, and J E Syväoja
Functions of eukaryotic DNA polymerases.
February 2003, Science of aging knowledge environment : SAGE KE,
U Hübscher, and H P Nasheuer, and J E Syväoja
[Inhibitors of eukaryotic DNA polymerases].
March 2002, Seikagaku. The Journal of Japanese Biochemical Society,
Copied contents to your clipboard!