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Antiviral activity of phosprenyl was studied in BALB/c mice infected with tick-borne encephalitis (TBE) virus. Up to 60% animals infected with TBE virus survived after 1-3 intramuscular injections of phosprenyl. The mortality in the untreated group infected with the virus was 100%. Direct antiviral effect of phosprenyl was studied in sensitive SPEV cells infected with TBE virus. The titer of the virus decreased 10-fold in the cells treated with the drug vs. untreated control cells. Phosprenyl stimulates some interleukins: gamma-interferon, tumor necrosis factor-alpha, and interleukin-6. The stimulating effect of the drug manifests in intact animals and in those infected with TBE virus and treated with phosprenyl. The prospects of further trials of the drug as a therapeutic and prophylactic agent in TBE are discussed.
S V Ozherelkov, and
A V Timofeev, and
G P Novikova, and
A V Deeva, and
A N Narovlianskiĭ, and
A V Sanin, and
A V Pronin
January 1993,
Voprosy virusologii,
S V Ozherelkov, and
A V Timofeev, and
G P Novikova, and
A V Deeva, and
A N Narovlianskiĭ, and
A V Sanin, and
A V Pronin
February 2023,
Antiviral research,
S V Ozherelkov, and
A V Timofeev, and
G P Novikova, and
A V Deeva, and
A N Narovlianskiĭ, and
A V Sanin, and
A V Pronin
January 1991,
Voprosy virusologii,
S V Ozherelkov, and
A V Timofeev, and
G P Novikova, and
A V Deeva, and
A N Narovlianskiĭ, and
A V Sanin, and
A V Pronin
January 1972,
Voprosy virusologii,
S V Ozherelkov, and
A V Timofeev, and
G P Novikova, and
A V Deeva, and
A N Narovlianskiĭ, and
A V Sanin, and
A V Pronin
October 1954,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
S V Ozherelkov, and
A V Timofeev, and
G P Novikova, and
A V Deeva, and
A N Narovlianskiĭ, and
A V Sanin, and
A V Pronin
April 1980,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
S V Ozherelkov, and
A V Timofeev, and
G P Novikova, and
A V Deeva, and
A N Narovlianskiĭ, and
A V Sanin, and
A V Pronin
June 2014,
Vaccine,
S V Ozherelkov, and
A V Timofeev, and
G P Novikova, and
A V Deeva, and
A N Narovlianskiĭ, and
A V Sanin, and
A V Pronin
May 1964,
Antibiotiki,
S V Ozherelkov, and
A V Timofeev, and
G P Novikova, and
A V Deeva, and
A N Narovlianskiĭ, and
A V Sanin, and
A V Pronin
December 1982,
Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...,
S V Ozherelkov, and
A V Timofeev, and
G P Novikova, and
A V Deeva, and
A N Narovlianskiĭ, and
A V Sanin, and
A V Pronin
September 1981,
Acta virologica,
