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OBJECTIVE Recent investigations have shown that amoxycillin possesses gastric protection properties in addition to its known antimicrobial effects. Therefore, this study was undertaken to investigate the potential gastric protection effects of amoxycillin and to determine its possible mechanism(s) of action in rats. METHODS The cold restraint stress model was used to produce gastric mucosal lesions. The gastric secretion studies were undertaken by using Shay's pylorus ligation technique. The antioxidant effect was studied by luminol dependent chemiluminescence technique in vitro. RESULTS Amoxycillin dose-dependently prevented cold restraint stress-induced mucus depletion and afforded protection. It inhibited indomethacin-stimulated gastric acid secretion with a high dose without affecting basal secretion. Furthermore, amoxycillin dose-dependently inhibited the phorbol myristate acetate-stimulated luminol-dependent chemiluminescence responses of isolated human poylmorphonuclear leukocytes in vitro. CONCLUSIONS These results suggest that mechanisms of gastric protection effects of amoxycillin may include inhibition of stimulated acid secretion, prevention of depletion of mucus and antioxidant properties.
A T Ali, and
O A al-Swayeh
April 1979,
Life sciences,
A T Ali, and
O A al-Swayeh
November 1990,
Japanese journal of pharmacology,
A T Ali, and
O A al-Swayeh
September 1997,
The International journal of neuroscience,
A T Ali, and
O A al-Swayeh
February 1981,
Life sciences,
A T Ali, and
O A al-Swayeh
January 2009,
General physiology and biophysics,
A T Ali, and
O A al-Swayeh
January 1992,
Digestion,
A T Ali, and
O A al-Swayeh
January 1997,
The Chinese journal of physiology,
A T Ali, and
O A al-Swayeh
September 2020,
Anatomy & cell biology,
A T Ali, and
O A al-Swayeh
December 2013,
Archives of pharmacal research,
A T Ali, and
O A al-Swayeh
May 1998,
General pharmacology,
