-transparent.png){kind=logo}
The expression of cyclooxygenase-2 (COX-2) and striatal dopamine (DA) depletion in BALB/cAnNcrj (BALB/c) mice following a neurotoxic dose of methamphetamine (METH) was investigated. METH-treatment (4 mg/kg x 4, 2 h intervals, s.c.) induced a significant hyperthermia and a persistent depletion of striatal DA levels 72 h after the treatment. COX-2, a marker of the cytotoxic effect of inflammation and oxidative stress and thiobarbituric acid (TBA) were significantly induced in the striatum 72 h after the METH-treatment, but not in the hippocampus. These results suggest that COX-2 may participate in METH-induced neurotoxicity in striatum.
Related Publications
T Kita, and
K Shimada, and
Y Mastunari, and
G C Wagner, and
K Kubo, and
T Nakashima
September 1998,
Neuropharmacology,
T Kita, and
K Shimada, and
Y Mastunari, and
G C Wagner, and
K Kubo, and
T Nakashima
October 2013,
Neuroscience letters,
T Kita, and
K Shimada, and
Y Mastunari, and
G C Wagner, and
K Kubo, and
T Nakashima
March 2011,
Current neuropharmacology,
T Kita, and
K Shimada, and
Y Mastunari, and
G C Wagner, and
K Kubo, and
T Nakashima
August 2021,
Research in pharmaceutical sciences,
T Kita, and
K Shimada, and
Y Mastunari, and
G C Wagner, and
K Kubo, and
T Nakashima
May 2005,
The Journal of pharmacology and experimental therapeutics,
T Kita, and
K Shimada, and
Y Mastunari, and
G C Wagner, and
K Kubo, and
T Nakashima
November 2011,
Synapse (New York, N.Y.),
T Kita, and
K Shimada, and
Y Mastunari, and
G C Wagner, and
K Kubo, and
T Nakashima
September 1995,
European journal of pharmacology,
T Kita, and
K Shimada, and
Y Mastunari, and
G C Wagner, and
K Kubo, and
T Nakashima
October 2018,
Iranian journal of allergy, asthma, and immunology,
T Kita, and
K Shimada, and
Y Mastunari, and
G C Wagner, and
K Kubo, and
T Nakashima
January 1993,
Journal of neural transmission. General section,
T Kita, and
K Shimada, and
Y Mastunari, and
G C Wagner, and
K Kubo, and
T Nakashima
July 2009,
Neuroscience,
