BIOMAT Database Logo BIOMAT Database Logo

Relation between thallium-201/iodine 123-BMIPP subtraction and fluorine 18 deoxyglucose polar maps in patients with hypertrophic cardiomyopathy. 2000

Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
Division of Tracer Kinetics, Biomedical Research Center, Osaka University Medical School, Suita, Japan.

BACKGROUND Clinical studies have shown discrepancies in the distribution of thallium-201 and iodine 123-beta-methyl-iodophenylpentadecanoic acid (BMIPP) in patients with hypertrophic cardiomyopathy (HCM). Myocardial uptake of fluorine 18 deoxyglucose (FDG) is increased in the hypertrophic area in HCM. RESULTS We examined whether the distribution of a Tl-201/BMIPP subtraction polar map correlates with that of an FDG polar map. We normalized to maximum count each Tl-201 and BMIPP bull's-eye polar map of 6 volunteers and obtained a standard Tl-201/BMIPP subtraction polar map by subtracting a normalized BMIPP bull's-eye polar map from a normalized Tl-201 bull's-eye polar map. The Tl-201/BMIPP subtraction polar map was then applied to 8 patients with HCM (mean age 65+/-12 years) to evaluate the discrepancy between Tl-201 and BMIPP distribution. We compared the Tl-201/BMIPP subtraction polar map with an FDG polar map. In patients with HCM, the Tl-201/BMIPP subtraction polar map showed a focal uptake pattern in the hypertrophic area similar to that of the FDG polar map. By quantitative analysis, the severity score of the Tl-201/BMIPP subtraction polar map was significantly correlated with the percent dose uptake of the FDG polar map. CONCLUSIONS These results suggest that this new quantitative method may be an alternative to FDG positron emission tomography for the routine evaluation of HCM.

UI MeSH Term Description Entries
D007457 Iodine Radioisotopes Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes. Radioisotopes, Iodine
D007462 Iodobenzenes Any derivative of BENZENE that contains IODINE.
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002312 Cardiomyopathy, Hypertrophic A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY). Cardiomyopathy, Hypertrophic Obstructive,Cardiomyopathies, Hypertrophic,Cardiomyopathies, Hypertrophic Obstructive,Hypertrophic Cardiomyopathies,Hypertrophic Cardiomyopathy,Hypertrophic Obstructive Cardiomyopathies,Hypertrophic Obstructive Cardiomyopathy,Obstructive Cardiomyopathies, Hypertrophic,Obstructive Cardiomyopathy, Hypertrophic
D005227 Fatty Acids Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed) Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D013382 Subtraction Technique Combination or superimposition of two images for demonstrating differences between them (e.g., radiograph with contrast vs. one without, radionuclide images using different radionuclides, radiograph vs. radionuclide image) and in the preparation of audiovisual materials (e.g., offsetting identical images, coloring of vessels in angiograms). Subtraction Technic,Subtraction Technics,Subtraction Techniques,Technic, Subtraction,Technics, Subtraction,Technique, Subtraction,Techniques, Subtraction

Related Publications

Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
Detection of perioperative coronary vasospasm on iodine-123-MIBG, thallium-201 and iodine-123-BMIPP myocardial SPECT images.
November 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
Outcome significance of thallium-201 and iodine-123-BMIPP perfusion-metabolism mismatch in preinfarction angina.
September 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
Detection of impaired fatty acid metabolism and dyskinesis in hypertrophic cardiomyopathy with iodine-123-BMIPP.
October 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
Localization of abnormal parathyroid gland(s) using thallium-201/iodine-123 subtraction scintigraphy in patients with primary hyperparathyroidism.
January 1987, Clinical nuclear medicine,
Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
Simultaneous dual myocardial imaging with iodine-123-beta-methyl iodophenyl-pentadecanoic acid (BMIPP) and thallium-201 in patients with coronary heart disease.
February 1994, Japanese circulation journal,
Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
Increased uptake of iodine-123-BMIPP in chronic ischemic heart disease: comparison with fluorine-18-FDG SPECT.
February 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
Comparison of iodine-125-BMIPP and thallium-201 in myocardial hypoperfusion.
September 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
[The mechanism of giant negative T wave in electrocardiogram in patients with apical hypertrophic cardiomyopathy: evaluation with thallium-201 and iodine-123 metaiodobenzylguanidine myocardial scintigraphy].
September 1996, Kaku igaku. The Japanese journal of nuclear medicine,
Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
Comparison of resting beta-methyl-iodophenyl pentadecanoic acid (BMIPP) and thallium-201 tomography using quantitative polar maps in patients with unstable angina.
February 1997, Japanese circulation journal,
Y Ito, and S Hasegawa, and H Yamaguchi, and J Yoshioka, and T Uehara, and T Nishimura
Metabolic myocardial viability assessment with iodine 123-16-iodo-3-methylhexadecanoic acid in recent myocardial infarction: comparison with thallium-201 and fluorine-18 fluorodeoxyglucose.
February 1997, European journal of nuclear medicine,
Copied contents to your clipboard!