-transparent.png){kind=logo}
Interleukin-1 (IL-1) is an inflammatory mediator that increases Cl- secretion in intestinal epithelial cells. To identify the signal transduction pathway(s) involved in IL-1's action, cells were treated with IL-1 and the levels of cyclooxygenase (COX) enzymes, prostaglandin E2 (PGE2) and phospholipase A2-activating protein (PLAP), and the activity of phospholipase A2 (PLA2) were measured. IL-1 caused concentration- and time-dependent increases in the levels of PLA2 activity, and/or in the levels of PLAP, COX-2 and PGE2. The IL-induced increase in PGE2 levels was biphasic, with the first peak due to the increase in PLAP levels, and the second peak due to the increase in COX-2 levels. This increase in PGE2 levels may provide a mechanism for acute and chronic inflammation in the intestine.
F R Homaidan, and
L Zhao, and
I Chakroun, and
C A Martin, and
R Burakoff
February 1991,
Brain research,
F R Homaidan, and
L Zhao, and
I Chakroun, and
C A Martin, and
R Burakoff
October 1990,
FEBS letters,
F R Homaidan, and
L Zhao, and
I Chakroun, and
C A Martin, and
R Burakoff
July 1993,
The Journal of clinical investigation,
F R Homaidan, and
L Zhao, and
I Chakroun, and
C A Martin, and
R Burakoff
February 1993,
Gastroenterology,
F R Homaidan, and
L Zhao, and
I Chakroun, and
C A Martin, and
R Burakoff
March 2000,
Gut,
F R Homaidan, and
L Zhao, and
I Chakroun, and
C A Martin, and
R Burakoff
January 1977,
Acta biochimica Polonica,
F R Homaidan, and
L Zhao, and
I Chakroun, and
C A Martin, and
R Burakoff
December 1998,
Gastroenterology,
F R Homaidan, and
L Zhao, and
I Chakroun, and
C A Martin, and
R Burakoff
October 1997,
Shock (Augusta, Ga.),
F R Homaidan, and
L Zhao, and
I Chakroun, and
C A Martin, and
R Burakoff
July 2009,
Microbial pathogenesis,
F R Homaidan, and
L Zhao, and
I Chakroun, and
C A Martin, and
R Burakoff
August 1995,
Kidney international,
