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Microsatellite instability (MSI) caused by the defective functions of mismatch repair genes plays an important role in the carcinogenesis of gastrointestinal tumors. However, little is known about the role of MSI in esophageal carcinogenesis. In the present study, we conducted microsatellite assays on 41 esophageal carcinomas and also on 44 dysplasias of the esophagus with 7 separate microsatellite loci. MSI was detected in 17 cases (42%) among 41 esophageal carcinomas. MSI negative cases revealed greater lymph node metastasis, metastasis at a more advanced stage, a higher recurrence level and a poorer prognosis (statistically not significant). In the analysis of dysplasias, MSI was detected in 26 lesions (59%) among 44 lesions. Interestingly, MSI was detected in 21 lesions (78%) from the mutator phenotype dysplasias, but detected in only 5 lesions (29%) from the non-mutator phenotype cases. Although the significance of MSI in esophageal carcinoma was not clear, these results indicate that MSI occurs in the early stage of esophageal carcinogenesis.
Y Kagawa, and
K Yoshida, and
T Hirai, and
T Toge, and
H Yokozaki, and
W Yasui, and
E Tahara
March 2005,
Yi chuan xue bao = Acta genetica Sinica,
Y Kagawa, and
K Yoshida, and
T Hirai, and
T Toge, and
H Yokozaki, and
W Yasui, and
E Tahara
January 1952,
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Y Kagawa, and
K Yoshida, and
T Hirai, and
T Toge, and
H Yokozaki, and
W Yasui, and
E Tahara
January 1990,
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Y Kagawa, and
K Yoshida, and
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T Toge, and
H Yokozaki, and
W Yasui, and
E Tahara
November 1998,
British journal of cancer,
Y Kagawa, and
K Yoshida, and
T Hirai, and
T Toge, and
H Yokozaki, and
W Yasui, and
E Tahara
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Molecular diagnosis & therapy,
Y Kagawa, and
K Yoshida, and
T Hirai, and
T Toge, and
H Yokozaki, and
W Yasui, and
E Tahara
September 2000,
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Y Kagawa, and
K Yoshida, and
T Hirai, and
T Toge, and
H Yokozaki, and
W Yasui, and
E Tahara
January 2003,
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology,
Y Kagawa, and
K Yoshida, and
T Hirai, and
T Toge, and
H Yokozaki, and
W Yasui, and
E Tahara
March 2009,
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Y Kagawa, and
K Yoshida, and
T Hirai, and
T Toge, and
H Yokozaki, and
W Yasui, and
E Tahara
December 2004,
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics,
Y Kagawa, and
K Yoshida, and
T Hirai, and
T Toge, and
H Yokozaki, and
W Yasui, and
E Tahara
March 1993,
The American journal of pathology,
