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Studies of antinuclear antibodies (ANA) were carried out in 39 cases of systemic scleroderma and for comparison in 19 cases of systemic lupus erythematosus (SLE) using indirect immunofluorescence (IF) methods under standard conditions. The results on three different substrates--monkey esophagus, guinea pig lip and rat liver--are reported. In 48.7% of scleroderma cases ANA showed a substrate specificity. The highest percentage of positive results in scleroderma was obtained on monkey esophagus (97.4%) and the lowest on rat liver (61.5%). In SLE, in contrast, only about 13% of the sera displayed such specificity. If only sera with substrate specificity are considered, the positive results on monkey esophagus and rat liver are 94.7% and 21.1%, respectively. Titers of sera reacting positively on 2 or 3 substrates were mostly in agreement, although some sera both in systemic scleroderma and SLE showed higher titers on monkey esophagus. The IF pattern was usually the same regardless of the substrate. Tests for ANA in scleroderma should be performed on at least 2 substrates simultaneously.
M Błaszczyk, and
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M Jarzabek-Chorzelska, and
S Jabłońska, and
T P Chorzelski
April 1977,
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M Błaszczyk, and
E H Beutner, and
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G Rzesa, and
M Jarzabek-Chorzelska, and
S Jabłońska, and
T P Chorzelski
January 1978,
The Journal of investigative dermatology,
M Błaszczyk, and
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M Jarzabek-Chorzelska, and
S Jabłońska, and
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November 1981,
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M Błaszczyk, and
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M Jarzabek-Chorzelska, and
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January 1982,
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M Błaszczyk, and
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May 1983,
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M Błaszczyk, and
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G Rzesa, and
M Jarzabek-Chorzelska, and
S Jabłońska, and
T P Chorzelski
February 1971,
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M Błaszczyk, and
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T P Chorzelski
March 1988,
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M Błaszczyk, and
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T Rogoziński, and
G Rzesa, and
M Jarzabek-Chorzelska, and
S Jabłońska, and
T P Chorzelski
December 1995,
The Journal of rheumatology,
M Błaszczyk, and
E H Beutner, and
T Rogoziński, and
G Rzesa, and
M Jarzabek-Chorzelska, and
S Jabłońska, and
T P Chorzelski
January 1972,
Przeglad dermatologiczny,
M Błaszczyk, and
E H Beutner, and
T Rogoziński, and
G Rzesa, and
M Jarzabek-Chorzelska, and
S Jabłońska, and
T P Chorzelski
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Arthritis and rheumatism,
