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The effect of poly-4-vinylpyridine and polyacrilic acid on production of antibodyforming cells to the sheep red blood cells in in vivo mixed cultures of T- and B-lymphocytes involved an obvious increase of the immune response. To a lesser extent theimmune response was increased in B-lymphocyte cultures, and no such effect was observed in T-lymphocyte cultures. The poly-4-vinlpyridine and polyacrilic acid were concluded to enhance cooperation between T- and B-lymphocytes and, probably, to replacethe T-lymphocytes function in B-mice.
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