Biomaterial Database

Shock sensitization of startle in the developing rat. 2000

R Richardson, and A Vishney

School of Psychology, Faculty of Life Sciences, The University of New South Wales, UNSW SYDNEY 2052, Australia.

Rats given a series of shocks exhibit a potentiated startle response to a loud acoustic stimulus compared to nonshocked animals. Experiment 1 showed that this shock sensitization of startle, like conditioned fear potentiation of startle to discrete cues, emerges relatively late in development (i.e., 23 days of age). Although different testing procedures were used in Experiment 2, preweanling rats still failed to exhibit the shock sensitization of startle effect. The failure to observe the shock sensitization of startle effect in preweanling rats was not due to age differences in contextual conditioning produced by the shock treatment (Experiment 3). The results of this study are discussed in terms of (a) the emergence of fear potentiation of startle during development, and (b) the relation between conditioned freezing and startle potentiation.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D003214	Conditioning, Classical	Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.	Reflex, Conditioned,Classical Conditioning,Classical Conditionings,Conditioned Reflex,Conditionings, Classical
D005239	Fear	The affective response to an actual current external danger which subsides with the elimination of the threatening condition.	Threat Cues,Threat Sensitivity,Cue, Threat,Fears,Sensitivity, Threat,Threat Cue,Threat Sensitivities
D000161	Acoustic Stimulation	Use of sound to elicit a response in the nervous system.	Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000375	Aging	The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	Senescence,Aging, Biological,Biological Aging
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001143	Arousal	Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system.	Vigilance, Cortical,Arousals,Cortical Vigilance
D013216	Reflex, Startle	A complex involuntary response to an unexpected strong stimulus. The reaction involves physical movement away from the stimulus, MUSCLE CONTRACTION and limb flexion, BLINKING, and changes in HEART RATE, BLOOD PRESSURE, and RESPIRATION.	Startle Reaction,Acoustic Startle Reflex,Reflex, Moro,Startle Response,Moro Reflex,Reaction, Startle,Reactions, Startle,Reflex, Acoustic Startle,Response, Startle,Responses, Startle,Startle Reactions,Startle Reflex,Startle Reflex, Acoustic,Startle Responses
D017207	Rats, Sprague-Dawley	A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.	Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus