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The effect of an acute non-specific inflammatory exudate with mitogenic activity on macrophages in culture has been tested on the spontaneous and PHA-induced DNA synthesis of spleen cells in vitro. Stimulatory effect of this exudate was observed on spontaneous DNA synthesis which was detectable over a range of 1 : 4 to 1 : 4,000 concentrations. After optimal PHA stimulation, an inhibition of mitogen-induced DNA synthesis was observed when the cells were exposed to the highest concentrations (up to 1 : 128) of the exudate. Thereafter, the phenomenon could be reversed and the stimulation was maximal at a concentration of 1 : 2,000. When a sub-optimal dose of PHA was used, the simulatory effect was more pronounced and detected from 1 : 8 up to 1 : 4,000 concentrations.
J P Giroud, and
I Florentin, and
M Pelletier
November 1972,
Experimental cell research,
J P Giroud, and
I Florentin, and
M Pelletier
February 1975,
Experimental cell research,
J P Giroud, and
I Florentin, and
M Pelletier
June 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J P Giroud, and
I Florentin, and
M Pelletier
January 1971,
International archives of allergy and applied immunology,
J P Giroud, and
I Florentin, and
M Pelletier
July 1970,
Journal of the Reticuloendothelial Society,
J P Giroud, and
I Florentin, and
M Pelletier
January 1976,
Archivum immunologiae et therapiae experimentalis,
J P Giroud, and
I Florentin, and
M Pelletier
November 1989,
Cell biology and toxicology,
J P Giroud, and
I Florentin, and
M Pelletier
January 1974,
Bollettino dell'Istituto sieroterapico milanese,
J P Giroud, and
I Florentin, and
M Pelletier
February 1969,
Experimental cell research,
J P Giroud, and
I Florentin, and
M Pelletier
July 1974,
Acta obstetrica et gynaecologica Japonica,
