Biomaterial Database

Membrane and bubble oxygenator: a clinical comparison in patients undergoing aortocoronary bypass procedures. 1979

L Alon, and M Turina, and R Gattiker

Forty patients undergoing aortocoronary bypass procedures were randomyl allocated to a bubble oxygenator group (20 patients) and a membrane oxygenator group (20 patients). Blood chemistry, hematology and hemodynamics before, during and after cardiopulmonary bypass were used to compare the two oxygenators. There was no mortality and no serious complications in both groups. A higher hemolysis, with significantly higher levels of lactic dehydrogenase and free plasma hemoglobin and a more pronounced reduction in platelet count were found in the patients perfused with the bubble oxygenator. These differences persisted for 24 hours after the operation; 48 hours after surgery no significant differences between the two groups could be detected. Postoperative blood loss, intra- and postoperative hemodynamics and pulmonary gas exchange were equal in both groups. These results show, that the routine use of membrane oxygenators brings only minor benefits; therefore it may be specially reserved for extended open-heart procedures and for operations in high risk patients.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010106	Oxygenators	Devices which mechanically oxygenate venous blood extracorporeally. They are used in combination with one or more pumps for maintaining circulation during open heart surgery and for assisting the circulation in patients seriously ill with some cardiac and pulmonary disorders. (UMDNS, 1999)	Oxygenator
D010107	Oxygenators, Membrane	Devices in which blood and oxygen are separated by a semipermeable membrane, generally of Teflon or polypropylene, across which gas exchange occurs. The membrane may be arranged as a series of parallel plates or as a number of hollow fibers; in the latter arrangement, the blood may flow inside the fibers, which are surrounded by gas, or the blood may flow outside the fibers and the gas inside the fibers. (Dorland, 28th ed)	Membrane Oxygenator,Membrane Oxygenators,Oxygenator, Membrane
D001784	Blood Gas Analysis	Measurement of oxygen and carbon dioxide in the blood.	Analysis, Blood Gas,Analyses, Blood Gas,Blood Gas Analyses,Gas Analyses, Blood,Gas Analysis, Blood
D003362	Cost-Benefit Analysis	A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. In contrast a cost effectiveness in general compares cost with qualitative outcomes.	Cost and Benefit,Cost-Benefit Data,Benefits and Costs,Cost Benefit,Cost Benefit Analysis,Cost-Utility Analysis,Costs and Benefits,Economic Evaluation,Marginal Analysis,Analyses, Cost Benefit,Analysis, Cost Benefit,Analysis, Cost-Benefit,Analysis, Cost-Utility,Analysis, Marginal,Benefit and Cost,Cost Benefit Analyses,Cost Benefit Data,Cost Utility Analysis,Cost-Benefit Analyses,Cost-Utility Analyses,Data, Cost-Benefit,Economic Evaluations,Evaluation, Economic,Marginal Analyses
D005260	Female		Females
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D006461	Hemolysis	The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	Haemolysis,Extravascular Hemolysis,Intravascular Hemolysis,Extravascular Hemolyses,Haemolyses,Hemolyses, Extravascular,Hemolyses, Intravascular,Hemolysis, Extravascular,Hemolysis, Intravascular,Intravascular Hemolyses
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man