Biomaterial Database

Sensitization of thymine and uracil to ionizing radiation by p-nitroacetophenone. 1975

A J Varghese

p-Nitroacetophenone (PNAP) alters the radiation chemistry of thymine and uracil in de-aerated aqueous solution. In the case of thymine, it increases the yield of radiolysis products by a factor of almost two, and cis glycol of thymine is the major product. With uracil, the yield of the dimeric product, which is the major radiolysis product in de-aerated aqueous solution, is considerably reduced and the yield of cis glycol is increased. When the irradiation is carried out in N2O-saturated solution, PNAP enhances the yeild of glycol by a factor of two. The effects of cupric sulphate on the radiation chemistry of uracil are analogous to those of PNAP. A mechanism, involving a reaction between PNAP and the hydroxyl radical adduct of the pyrimidine proceeding through a one-step process, is postulated for the enhanced formation of glycol.

UI	MeSH Term	Description	Entries
D009574	Nitro Compounds	Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.	Nitrated Compounds
D011830	Radiation Effects	The effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals.	Effects, Radiation,Effect, Radiation,Radiation Effect
D011838	Radiation-Sensitizing Agents	Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.	Radiation Sensitizer,Radiosensitizing Agent,Radiosensitizing Agents,Agents, Radiation-Sensitizing,Radiation Sensitizers,Radiation Sensitizing Agents,Radiation-Sensitizing Drugs,Radiation-Sensitizing Effect,Radiation-Sensitizing Effects,Radiosensitizing Drugs,Radiosensitizing Effect,Radiosensitizing Effects,Agent, Radiosensitizing,Agents, Radiation Sensitizing,Agents, Radiosensitizing,Drugs, Radiation-Sensitizing,Drugs, Radiosensitizing,Effect, Radiation-Sensitizing,Effect, Radiosensitizing,Effects, Radiation-Sensitizing,Effects, Radiosensitizing,Radiation Sensitizing Drugs,Radiation Sensitizing Effect,Radiation Sensitizing Effects,Sensitizer, Radiation,Sensitizers, Radiation,Sensitizing Agents, Radiation
D003037	Cobalt Radioisotopes	Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.	Radioisotopes, Cobalt
D005720	Gamma Rays	Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.	Gamma Wave,Gamma Radiation,Nuclear X-Rays,Radiation, Gamma,X-Rays, Nuclear,Gamma Radiations,Gamma Ray,Gamma Waves,Nuclear X Rays,Nuclear X-Ray,Ray, Gamma,Wave, Gamma,Waves, Gamma,X Rays, Nuclear,X-Ray, Nuclear
D000098	Acetophenones	Derivatives of the simplest aromatic ketone acetophenone (of general formula C6H5C(O)CH3).
D013941	Thymine	One of four constituent bases of DNA.	5-Methyluracil,5 Methyluracil
D014498	Uracil	One of four nucleotide bases in the nucleic acid RNA.