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Cotinine is the major proximate metabolite of nicotine. The aims of our study were to assess the pharmacokinetics of oral cotinine comparing the use of saliva and plasma concentrations, and to characterize the subjective and cardiovascular effects of oral cotinine in nonsmokers. The clearance and half-life of cotinine measured using plasma or saliva concentrations were similar. There was no change in heart rate or blood pressure, and no differences in subjective response with cotinine compared to placebo. We conclude that administration of oral cotinine with measurement in saliva samples is easy, safe, and provides an accurate estimate of systemic clearance and half-life of cotinine.
S Zevin, and
P Jacob, and
P Geppetti, and
N L Benowitz
January 1968,
Therapia Hungarica (English edition),
S Zevin, and
P Jacob, and
P Geppetti, and
N L Benowitz
January 1968,
Therapia Hungarica,
S Zevin, and
P Jacob, and
P Geppetti, and
N L Benowitz
January 1974,
Journal of clinical pharmacology,
S Zevin, and
P Jacob, and
P Geppetti, and
N L Benowitz
September 1968,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
S Zevin, and
P Jacob, and
P Geppetti, and
N L Benowitz
August 1984,
Photo-dermatology,
S Zevin, and
P Jacob, and
P Geppetti, and
N L Benowitz
September 1972,
La Clinica terapeutica,
S Zevin, and
P Jacob, and
P Geppetti, and
N L Benowitz
January 2001,
Current problems in cancer,
S Zevin, and
P Jacob, and
P Geppetti, and
N L Benowitz
January 1980,
Cancer chemotherapy and pharmacology,
S Zevin, and
P Jacob, and
P Geppetti, and
N L Benowitz
January 1979,
Advances in internal medicine,
S Zevin, and
P Jacob, and
P Geppetti, and
N L Benowitz
August 1970,
[Kango gijutsu] : [Nursing technique],
