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Multiple sclerosis (MS) is a multifactorial disease in which genetic and environmental factors apparently have a major influence on the susceptibility and course of the disease. In the present study we have investigated the genetic basis and subclass levels of IgG in MS. Hundred and thirty-six Norwegian patients with MS and 92 controls were genotyped for IgG allotypes of the GM and KM systems. IgG and IgG subclasses were quantified in sera from 115 MS patients and 20 controls. Neither GM nor KM allo-, haplo- or genotypes were significantly correlated with susceptibility, severity or course of the disease. The G1M (3) (3), G2M (23) (23) and G3M (5) (5) allotypes were significantly correlated with high serum levels of IgG3, whereas high IgG2 levels were correlated with G1M (3) (3) and G2M (23) (23) in both patients and controls. Serum levels of IgG subclasses were not significantly correlated with course or severity of the disease. The results indicate no major role for IgG allotypes or IgG subclass levels in the pathogenesis of MS.
G Raknes, and
J A Fernandes Filho, and
J P Pandey, and
K M Myhr, and
E Ulvestad, and
H Nyland, and
C A Vedeler
January 1988,
Annals of the New York Academy of Sciences,
G Raknes, and
J A Fernandes Filho, and
J P Pandey, and
K M Myhr, and
E Ulvestad, and
H Nyland, and
C A Vedeler
March 1982,
Scandinavian journal of immunology,
G Raknes, and
J A Fernandes Filho, and
J P Pandey, and
K M Myhr, and
E Ulvestad, and
H Nyland, and
C A Vedeler
January 2014,
Frontiers in immunology,
G Raknes, and
J A Fernandes Filho, and
J P Pandey, and
K M Myhr, and
E Ulvestad, and
H Nyland, and
C A Vedeler
July 1990,
Acta neurologica Scandinavica,
G Raknes, and
J A Fernandes Filho, and
J P Pandey, and
K M Myhr, and
E Ulvestad, and
H Nyland, and
C A Vedeler
January 1993,
Neurologia i neurochirurgia polska,
G Raknes, and
J A Fernandes Filho, and
J P Pandey, and
K M Myhr, and
E Ulvestad, and
H Nyland, and
C A Vedeler
May 1996,
European journal of neurology,
G Raknes, and
J A Fernandes Filho, and
J P Pandey, and
K M Myhr, and
E Ulvestad, and
H Nyland, and
C A Vedeler
October 1982,
Immunology today,
G Raknes, and
J A Fernandes Filho, and
J P Pandey, and
K M Myhr, and
E Ulvestad, and
H Nyland, and
C A Vedeler
December 1983,
Clinical and experimental immunology,
G Raknes, and
J A Fernandes Filho, and
J P Pandey, and
K M Myhr, and
E Ulvestad, and
H Nyland, and
C A Vedeler
January 1974,
Humangenetik,
G Raknes, and
J A Fernandes Filho, and
J P Pandey, and
K M Myhr, and
E Ulvestad, and
H Nyland, and
C A Vedeler
October 1982,
Journal of immunogenetics,
