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Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors. 2000
K Oritani, and
K L Medina, and
Y Tomiyama, and
J Ishikawa, and
Y Okajima, and
M Ogawa, and
T Yokota, and
K Aoyama, and
I Takahashi, and
P W Kincade, and
Y Matsuzawa
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan.
We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon alpha/beta receptors and induces interferon regulatory factor-1, it may represent a previously unknown type I interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.
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