BIOMAT Database Logo BIOMAT Database Logo

In vitro proliferative reactions by lymphocytes from both responder and "low" responder mice to (T,G)-A--L. 1976

J J Oppenheim, and E Mozes, and M Sela

In summary (T,G)-A--L can induce specific in vitro lymphoproliferative reactions in LNC from immunized mice. From 3-8 weeks after immunization lymphocytes from responder mice react to a much greater degree than from low responders. These proliferative reactions are not specifically enhanced by supernatants of "educated" T cells. However, 2 to 3 months after immunization the lymphoproliferative response of the low responders rises to the same level as that of responder mice.

UI MeSH Term Description Entries
D007156 Immunologic Memory The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus. Immune Memory,Immunological Memory,Memory, Immunologic,Immune Memories,Immunologic Memories,Immunological Memories,Memory, Immune,Memory, Immunological
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008809 Mice, Inbred C3H An inbred strain of mouse that is used as a general purpose strain in a wide variety of RESEARCH areas including CANCER; INFECTIOUS DISEASES; sensorineural, and cardiovascular biology research. Mice, C3H,Mouse, C3H,Mouse, Inbred C3H,C3H Mice,C3H Mice, Inbred,C3H Mouse,C3H Mouse, Inbred,Inbred C3H Mice,Inbred C3H Mouse
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005796 Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. Cistron,Gene,Genetic Materials,Cistrons,Genetic Material,Material, Genetic,Materials, Genetic

Related Publications

J J Oppenheim, and E Mozes, and M Sela
Carrier function of the polypeptides (T,G)-A-L and (H,G)-A--L in high and low responder mice.
December 1973, European journal of immunology,
J J Oppenheim, and E Mozes, and M Sela
In vitro studies on H-2 linked unresponsiveness. 1. Normal helper cells to (T,G)-A-L and GAT in low and non-responder mice.
March 1977, Immunology,
J J Oppenheim, and E Mozes, and M Sela
In vitro proliferative response to living schistosomula by T lymphocytes from mice infected with Schistosoma mansoni.
August 1981, Parasitology,
J J Oppenheim, and E Mozes, and M Sela
Genetic control of the immune response: in vitro stimulation of lymphocytes by (T,G)-A--L, (H,G)-A--L, and (Phe,G)-A--L.
October 1974, The Journal of experimental medicine,
J J Oppenheim, and E Mozes, and M Sela
Suppressor cell induction in vitro. VI. Production of suppressor factors to synthetic polypeptides GAT and (T,G)-A--L from cells of responder and nonresponder mice.
January 1979, Journal of immunology (Baltimore, Md. : 1950),
J J Oppenheim, and E Mozes, and M Sela
Contribution of B and T lymphocytes to in vitro chicken proliferative spleen cell reactions to antigens.
January 1973, Advances in experimental medicine and biology,
J J Oppenheim, and E Mozes, and M Sela
T cell response to myoglobin: a comparison of T cell clones in high-responder and low-responder mice.
September 1988, European journal of immunology,
J J Oppenheim, and E Mozes, and M Sela
[Autoimmune response to thyroglobulin. Proliferative response to thyroglobulin fragments in low responder mice].
January 1992, Arerugi = [Allergy],
J J Oppenheim, and E Mozes, and M Sela
Antigen-reactive T clones. III. Low responder antigen-presenting cells function effectively to present antigen to selected T cell clones derived from (High Responder x Low Responder)F1 mice.
September 1981, The Journal of experimental medicine,
J J Oppenheim, and E Mozes, and M Sela
H-2 haplotype-specific conversion of the Ir gene phenotype expressed by low-responder mice immunized with a p-azophenylarsonate conjugate of (T,G)-A--L.
May 1982, Journal of immunology (Baltimore, Md. : 1950),
Copied contents to your clipboard!