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Male Wistar rats were fed either a balanced diet whose protein source was a mixture of amino acids (diet 1), or a similar diet which differed only in having 48% less the quantity of the sulfur-containing amino acids methionine and cystine (diet 2). The diets were given either continuously for 1 month or for 15 days after a protein-free diet. Both diets 1 and 2 permitted good growth of rats and relatively stable microsomal protein content. Protein depletion decreased the total proteins, total phospholipids, and cytochrome P-450 content, and it strongly increased UDP-glucuronosyltransferase activity in rat-liver microsomes. Repletion with diet 1 restored those values, to the level found in control rats. However, diet 2, given continuously induced an increase in UDP-glucuronosyltransferase activity and in the cytochrome P-450 concentration. Since high UDP-glucuronosyltransferase activity was related to lessened amounts of sulfur-containing amino acids in the diet, we discuss the possible effect of methionine and cystine on the regulation of glucuronoconjugation in relation to sulfoconjugation.
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D Steimetz, and
A M Batt, and
B Poullain, and
G Siest, and
G Debry
May 1982,
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J Magdalou, and
D Steimetz, and
A M Batt, and
B Poullain, and
G Siest, and
G Debry
January 1981,
Annals of nutrition & metabolism,
J Magdalou, and
D Steimetz, and
A M Batt, and
B Poullain, and
G Siest, and
G Debry
July 1970,
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J Magdalou, and
D Steimetz, and
A M Batt, and
B Poullain, and
G Siest, and
G Debry
June 1971,
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J Magdalou, and
D Steimetz, and
A M Batt, and
B Poullain, and
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October 1989,
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J Magdalou, and
D Steimetz, and
A M Batt, and
B Poullain, and
G Siest, and
G Debry
January 1983,
International journal of clinical pharmacology research,
J Magdalou, and
D Steimetz, and
A M Batt, and
B Poullain, and
G Siest, and
G Debry
January 1998,
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J Magdalou, and
D Steimetz, and
A M Batt, and
B Poullain, and
G Siest, and
G Debry
January 1991,
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J Magdalou, and
D Steimetz, and
A M Batt, and
B Poullain, and
G Siest, and
G Debry
August 1971,
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J Magdalou, and
D Steimetz, and
A M Batt, and
B Poullain, and
G Siest, and
G Debry
July 1977,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
