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The mechanisms that determine whether receptor stimulation leads to lymphocyte tolerance versus activation remain poorly understood. We have used rat insulin promoter (RIP)-gp/P14 double-transgenic mice expressing the lymphocytic choriomeningitis virus (LCMV) glycoprotein (gp) on pancreatic beta-islet cells together with T cells expressing an LCMV-gp-specific T cell receptor to assess the requirements for the induction of autoimmunity. Our studies have shown that administration of the gp peptide gp33 leads to the activation of P14-transgenic T cells, as measured by the upregulation of activation markers and the induction of effector cytotoxic activity. This treatment also leads to expansion and deletion of P14 T cells. Despite the induction of cytotoxic T lymphocyte activity, peptide administration is not sufficient to induce diabetes. However, the administration of gp peptide together with an activating anti-CD40 antibody rapidly induces diabetes. These findings suggest that the induction of tolerance versus autoimmunity is determined by resting versus activated antigen-presenting cells.
K M Garza, and
S M Chan, and
R Suri, and
L T Nguyen, and
B Odermatt, and
S P Schoenberger, and
P S Ohashi
January 2002,
Allergy,
K M Garza, and
S M Chan, and
R Suri, and
L T Nguyen, and
B Odermatt, and
S P Schoenberger, and
P S Ohashi
June 2020,
Scandinavian journal of immunology,
K M Garza, and
S M Chan, and
R Suri, and
L T Nguyen, and
B Odermatt, and
S P Schoenberger, and
P S Ohashi
May 2024,
Advanced drug delivery reviews,
K M Garza, and
S M Chan, and
R Suri, and
L T Nguyen, and
B Odermatt, and
S P Schoenberger, and
P S Ohashi
September 2007,
American journal of reproductive immunology (New York, N.Y. : 1989),
K M Garza, and
S M Chan, and
R Suri, and
L T Nguyen, and
B Odermatt, and
S P Schoenberger, and
P S Ohashi
January 2020,
Frontiers in immunology,
K M Garza, and
S M Chan, and
R Suri, and
L T Nguyen, and
B Odermatt, and
S P Schoenberger, and
P S Ohashi
January 2001,
Immunologic research,
K M Garza, and
S M Chan, and
R Suri, and
L T Nguyen, and
B Odermatt, and
S P Schoenberger, and
P S Ohashi
March 2020,
Cellular immunology,
K M Garza, and
S M Chan, and
R Suri, and
L T Nguyen, and
B Odermatt, and
S P Schoenberger, and
P S Ohashi
December 2003,
Nature medicine,
K M Garza, and
S M Chan, and
R Suri, and
L T Nguyen, and
B Odermatt, and
S P Schoenberger, and
P S Ohashi
December 2009,
Hematology/oncology clinics of North America,
K M Garza, and
S M Chan, and
R Suri, and
L T Nguyen, and
B Odermatt, and
S P Schoenberger, and
P S Ohashi
August 2009,
Innate immunity,
