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We studied the effects of a train of 30 pulses of repetitive transcranial magnetic stimulation (rTMS) at frequencies of 5 and 15 Hz and at an intensity of 120% of resting motor threshold on human motor cortex excitability. Intracortical inhibition (ICI) and intracortical facilitation (ICF) after rTMS were tested by a conditioning-test designed paired-pulse paradigm. After 15 Hz rTMS, ICI was significantly reduced for 3.2 min, ICF was enhanced for 1.5 min, muscle evoked potentials from single TMS were increased in the first 30 s only. After 5 Hz rTMS ICI was significantly reduced in the first 32 s. We conclude that high-frequency suprathreshold rTMS transiently suppresses the activity of the intracortical inhibitory circuitry and, with a different time course, increases the excitability of the excitatory circuitry.
T Wu, and
M Sommer, and
F Tergau, and
W Paulus
July 2019,
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
T Wu, and
M Sommer, and
F Tergau, and
W Paulus
October 2021,
Respiratory physiology & neurobiology,
T Wu, and
M Sommer, and
F Tergau, and
W Paulus
May 2000,
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
T Wu, and
M Sommer, and
F Tergau, and
W Paulus
September 2008,
Neurological research,
T Wu, and
M Sommer, and
F Tergau, and
W Paulus
April 2020,
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society,
T Wu, and
M Sommer, and
F Tergau, and
W Paulus
January 2017,
Archives of oral biology,
T Wu, and
M Sommer, and
F Tergau, and
W Paulus
January 2016,
Socioaffective neuroscience & psychology,
T Wu, and
M Sommer, and
F Tergau, and
W Paulus
January 2000,
Muscle & nerve,
T Wu, and
M Sommer, and
F Tergau, and
W Paulus
October 2006,
Experimental brain research,
T Wu, and
M Sommer, and
F Tergau, and
W Paulus
April 2020,
Neuroscience letters,
