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It was shown that bilirubin in its unconjugated form does not only harm the central nervous system. Clinical observations indicate that the toxic effect under certain conditions affects also the heart. In a simple experimental model the influence of free bilirubin on the activity of the heart was investigated. In 69 adult frogs the heart was isolated and exposed sequentially to solutions of different bilirubin concentrations while the heart actions were registered. There was no significant change in the activity of the heart under the influence of bilirubin although concentrations were reached which according to the results of other authors harm cell cultures or evoke in the newborn disturbances in various organs. As a possible explanation, the nonsusceptibility of the heart muscle to bilirubin, the short duration of exposure, and the different behavior of newborn and adult organs is discussed.
U Mittelstädt, and
J Biester, and
K Sandhage
May 1952,
Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere,
U Mittelstädt, and
J Biester, and
K Sandhage
July 1964,
Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere,
U Mittelstädt, and
J Biester, and
K Sandhage
April 1965,
Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere,
U Mittelstädt, and
J Biester, and
K Sandhage
January 1951,
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
U Mittelstädt, and
J Biester, and
K Sandhage
January 1963,
Zeitschrift fur die gesamte experimentelle Medizin,
U Mittelstädt, and
J Biester, and
K Sandhage
January 1967,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
U Mittelstädt, and
J Biester, and
K Sandhage
January 1962,
Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere,
U Mittelstädt, and
J Biester, and
K Sandhage
January 1954,
Zeitschrift fur Biologie,
U Mittelstädt, and
J Biester, and
K Sandhage
January 1973,
The Journal of pharmacology and experimental therapeutics,
U Mittelstädt, and
J Biester, and
K Sandhage
March 1967,
Der Anaesthesist,
