Biomaterial Database

Heterogeneity of the protein moiety of carcinoembryonic antigens. 1976

A C Wang, and C Banjo, and A Fuks, and J Shuster, and P Gold

N-terminal amino acid sequences were determined for the protein moiety of carcinoembryonic antigen (CEA) isolated from three colon cancers that had metastasized to the liver. The results showed that the polypeptide portion of CEA preparations isolated from different tumors are not identical. Furthermore, each CEA preparation appeared to be heterogeneous within itself, since multiple amino acid residues were recovered at most of the positions following stepwise cleavage of the protein moiety of CEA molecules by automatic Edman degradation.

UI	MeSH Term	Description	Entries
D010455	Peptides	Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS.	Peptide,Polypeptide,Polypeptides
D002272	Carcinoembryonic Antigen	A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.	Antigens, CD66e,CD66e Antigen,Antigen, CD66e,Antigen, Carcinoembryonic,CD66e Antigens
D005770	Gastrointestinal Neoplasms	Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.	Gastrointestinal Cancer,Cancer of Gastrointestinal Tract,Cancer of the Gastrointestinal Tract,Neoplasms, Gastrointestinal,Cancer, Gastrointestinal,Cancers, Gastrointestinal,Gastrointestinal Cancers,Gastrointestinal Neoplasm,Gastrointestinal Tract Cancer,Gastrointestinal Tract Cancers,Neoplasm, Gastrointestinal
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000595	Amino Acid Sequence	The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.	Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D015478	Antigens, Heterophile	Antigens stimulating the formation of, or combining with heterophile antibodies. They are cross-reacting antigens found in phylogenetically unrelated species.	Antigens, Heterogenetic,Antigens, Xenogeneic,H-D Antigens,Hanganutziu-Deicher Antigen,Hanganutziu-Deicher Antigens,Heteroantigens,Heterologous Antigen,Heterologous Antigens,Heterophile Antigen,Heterophile Antigens,Paul-Bunnell Antigens,Xenoantigen,Xenoantigens,Antigens, Heterologous,Antigens, Heterophil,Antigens, Xenogenic,Heterogenetic Antigens,Antigen, Hanganutziu-Deicher,Antigen, Heterologous,Antigen, Heterophile,Antigens, H-D,Antigens, Hanganutziu-Deicher,Antigens, Paul-Bunnell,H D Antigens,Hanganutziu Deicher Antigen,Hanganutziu Deicher Antigens,Heterophil Antigens,Paul Bunnell Antigens,Xenogeneic Antigens,Xenogenic Antigens