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Forty-six neonates with hypoxemia were treated with tolazoline, a pulmonary vasodilator, within the first two days of life. Eight of ten (80%) infants without apparent lung disease responded with a mean increase in PaO2 of 116 torr within one hour of beginning tolazoline infusions. One of the responding infants and two nonresponders died. Thirty-six additional infants with a variety of pulmonary disorders had severe hypoxemia which was refractory to mechanical ventilation. Twenty-one (58%) responded with a mean increase in PaO2 of 130 torr within one hour after beginning tolazoline and 13 (62%) of these survived. Fifteen patients had little or no improvement in PaO2 following tolazoline and only three (20%) of these infants survived. Responders could not be distinguished from nonresponders by clinical or laboratory features prior to therapy with tolazoline. Fourteen infants experienced complications possibly related to tolazoline.
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P Sunshine, and
J D Johnson, and
R P Wennberg, and
A Hackel, and
D F Merten, and
A L Bartoletti, and
N H Silverman
January 1980,
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B W Goetzman, and
P Sunshine, and
J D Johnson, and
R P Wennberg, and
A Hackel, and
D F Merten, and
A L Bartoletti, and
N H Silverman
March 1986,
Pediatrics,
B W Goetzman, and
P Sunshine, and
J D Johnson, and
R P Wennberg, and
A Hackel, and
D F Merten, and
A L Bartoletti, and
N H Silverman
January 1984,
Pediatric pharmacology (New York, N.Y.),
B W Goetzman, and
P Sunshine, and
J D Johnson, and
R P Wennberg, and
A Hackel, and
D F Merten, and
A L Bartoletti, and
N H Silverman
September 1993,
Pediatrics,
B W Goetzman, and
P Sunshine, and
J D Johnson, and
R P Wennberg, and
A Hackel, and
D F Merten, and
A L Bartoletti, and
N H Silverman
January 1972,
Journal of pediatric surgery,
B W Goetzman, and
P Sunshine, and
J D Johnson, and
R P Wennberg, and
A Hackel, and
D F Merten, and
A L Bartoletti, and
N H Silverman
January 1985,
Pediatric pharmacology (New York, N.Y.),
B W Goetzman, and
P Sunshine, and
J D Johnson, and
R P Wennberg, and
A Hackel, and
D F Merten, and
A L Bartoletti, and
N H Silverman
December 1996,
Acta paediatrica (Oslo, Norway : 1992),
B W Goetzman, and
P Sunshine, and
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A Hackel, and
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A L Bartoletti, and
N H Silverman
October 1979,
The Journal of pediatrics,
B W Goetzman, and
P Sunshine, and
J D Johnson, and
R P Wennberg, and
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D F Merten, and
A L Bartoletti, and
N H Silverman
March 1967,
International journal of biometeorology,
B W Goetzman, and
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N H Silverman
August 1979,
Pediatric research,
