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Radiotherapy can cause infertility in both men and women. However, few data are available concerning the effects of radioiodine therapy for thyroid carcinoma on testicular function. We investigated 25 men (age 23-73 years) with differentiated thyroid carcinoma in a longitudinal prospective trial. Follicle-stimulating hormone (FSH), inhibin B, luteinising hormone (LH) and testosterone were measured before (n = 25) and 3 months (n = 11), 6 months (n = 18), 12 months (n = 22), and 18 months (n = 18) after radioiodine therapy [radioiodine dose (mean +/- SEM): 9.8+/-0.89 GBq]. Before therapy, FSH was 5.4+/-0.77 IU/l; it increased significantly (P<0.001) to 21.3+/-2.4 IU/l after 6 months and fell to 7.4+/-1.3 IU/l after 18 months (normal range: 1.8-9.2 IU/l). Inhibin B was significantly decreased (P<0.001) from 178+/-25.3 pg/ml before therapy to 22.2+/-5.5 pg/ml after 3 and 29.4+/-5.7 pg/ml after 6 months and rose to 154+/-23.3 pg/ml after 18 months (normal range 75-350 pg/ml). LH and testosterone were within the normal range during the whole study (1.6-9.2 IU/l and 10.4-34.7 nmol/l, respectively). LH was significantly increased (P<0.001) from 2.8+/-0.33 IU/l before therapy to 5.9+/-0.69 IU/l 6 months after therapy and then fell slowly to 4.0+/-0.45 IU/l after 18 months. Total testosterone was significantly increased (P<0.01) from 12.8+/-0.99 nmol/l at baseline to 19.8+/-1.7 nmol/l after 12 months and 19.6+/-1.7 nmol/l after 18 months. The testosterone/LH ratio (normal range: 3.3-17.9 nmol/IU) fell from 5.8+/-0.66 nmol/IU to 3.0+/-0.36 nmol/IU after 3 months (P<0.01); it remained close to the latter value after 6 months (3.4+/-0.49 nmol/IU) and then rose to 5.5+/-0.6 nmol/IU after 18 months. In conclusion, 3 and 6 months after radioiodine therapy all patients showed elevated FSH and decreased inhibin B levels, reflecting severely impaired spermatogenesis. At the same time a compensated insufficiency of the Leydig cell function was observed. Eighteen months after the last radioiodine therapy, mean values of gonadal function had completely recovered.
M Wichers, and
E Benz, and
H Palmedo, and
H J Biersack, and
F Grünwald, and
D Klingmüller
July 2006,
Thyroid : official journal of the American Thyroid Association,
M Wichers, and
E Benz, and
H Palmedo, and
H J Biersack, and
F Grünwald, and
D Klingmüller
December 1959,
Journal of the American Medical Association,
M Wichers, and
E Benz, and
H Palmedo, and
H J Biersack, and
F Grünwald, and
D Klingmüller
September 1994,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
M Wichers, and
E Benz, and
H Palmedo, and
H J Biersack, and
F Grünwald, and
D Klingmüller
December 1988,
American journal of surgery,
M Wichers, and
E Benz, and
H Palmedo, and
H J Biersack, and
F Grünwald, and
D Klingmüller
June 1971,
Lancet (London, England),
M Wichers, and
E Benz, and
H Palmedo, and
H J Biersack, and
F Grünwald, and
D Klingmüller
November 1984,
Vrachebnoe delo,
M Wichers, and
E Benz, and
H Palmedo, and
H J Biersack, and
F Grünwald, and
D Klingmüller
January 1951,
Langenbecks Archiv fur klinische Chirurgie ... vereinigt mit Deutsche Zeitschrift fur Chirurgie,
M Wichers, and
E Benz, and
H Palmedo, and
H J Biersack, and
F Grünwald, and
D Klingmüller
January 1954,
Acta radiologica. Supplementum,
M Wichers, and
E Benz, and
H Palmedo, and
H J Biersack, and
F Grünwald, and
D Klingmüller
June 2001,
Saudi medical journal,
M Wichers, and
E Benz, and
H Palmedo, and
H J Biersack, and
F Grünwald, and
D Klingmüller
December 1989,
Meditsinskaia radiologiia,
