-transparent.png){kind=logo}
A subchronic toxicity study of chitin, a natural structural component of crustacean shells, was performed in F344 rats by feeding of the powdered diet containing 5%, 1.7%, 0.6%, 0.2%, and 0% concentrations of the substance. Each group consisted of 10 males and 10 females. All animals survived until the end of the experiment. There were no changes indicating obvious toxicity of chitin in the clinical signs, body weight, food intake, hematology, serum biochemistry, or histopathological findings, except a slight decrease in body weight gain in the 5% chitin-treated males. Although the mechanism is unclear, the suppression of body weight gain may be due to the slight decrease in caloric content of the food in the 5% chitin-treated animals, a change unrelated to toxicity. Thus, there was no obvious toxicity of chitin in F344 rats at concentrations up to 5% in the diet for 13 weeks.
N Niho, and
T Tamura, and
K Toyoda, and
C Uneyama, and
M Shibutani, and
M Hirose
January 1995,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
N Niho, and
T Tamura, and
K Toyoda, and
C Uneyama, and
M Shibutani, and
M Hirose
December 2014,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
N Niho, and
T Tamura, and
K Toyoda, and
C Uneyama, and
M Shibutani, and
M Hirose
October 2003,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
N Niho, and
T Tamura, and
K Toyoda, and
C Uneyama, and
M Shibutani, and
M Hirose
January 1999,
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences,
N Niho, and
T Tamura, and
K Toyoda, and
C Uneyama, and
M Shibutani, and
M Hirose
January 1998,
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences,
N Niho, and
T Tamura, and
K Toyoda, and
C Uneyama, and
M Shibutani, and
M Hirose
January 2008,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
N Niho, and
T Tamura, and
K Toyoda, and
C Uneyama, and
M Shibutani, and
M Hirose
January 1996,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
N Niho, and
T Tamura, and
K Toyoda, and
C Uneyama, and
M Shibutani, and
M Hirose
December 2018,
Regulatory toxicology and pharmacology : RTP,
N Niho, and
T Tamura, and
K Toyoda, and
C Uneyama, and
M Shibutani, and
M Hirose
January 1994,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
N Niho, and
T Tamura, and
K Toyoda, and
C Uneyama, and
M Shibutani, and
M Hirose
January 1997,
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences,
