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A family is described in which 5 out of 8 children had a marked bleeding disorder. The children showed prolonged bleeding times, abnormal platelet retention upon passage of blood through a glass bead column, the Willebrand factor activity as measured by ristocetin in a washed platelet system was low. Factor VIII/von Willebrand factor protein levels were normal even so the factor VIII-procoagulant activity. Even the parents and one child without any bleeding tendency and normal bleeding times had a reduced Willebrand factor activity. In all these patients evidence of an abnormal protein was observed on crossed antigen-antibody electrophoresis indicating a qualitative defect of the factor VIII/von Willebrand factor protein.
D Böttcher, and
K Hasler, and
A H Sutor, and
D Mair
November 1984,
Deutsche medizinische Wochenschrift (1946),
D Böttcher, and
K Hasler, and
A H Sutor, and
D Mair
January 1973,
Medizinische Klinik,
D Böttcher, and
K Hasler, and
A H Sutor, and
D Mair
January 1990,
Retina (Philadelphia, Pa.),
D Böttcher, and
K Hasler, and
A H Sutor, and
D Mair
September 2010,
Journal of thrombosis and haemostasis : JTH,
D Böttcher, and
K Hasler, and
A H Sutor, and
D Mair
June 1978,
Die Medizinische Welt,
D Böttcher, and
K Hasler, and
A H Sutor, and
D Mair
January 1952,
Zdravstveni vestnik,
D Böttcher, and
K Hasler, and
A H Sutor, and
D Mair
June 1973,
Zeitschrift fur arztliche Fortbildung,
D Böttcher, and
K Hasler, and
A H Sutor, and
D Mair
January 1982,
Acta medica Austriaca. Supplement,
D Böttcher, and
K Hasler, and
A H Sutor, and
D Mair
May 1967,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
D Böttcher, and
K Hasler, and
A H Sutor, and
D Mair
February 1979,
The American journal of medicine,
