-transparent.png){kind=logo}
The effects of fluoxetine, which is a selective inhibitor of serotonin reuptake (SSRI) have been studied on the intraocular pressure (IOP) in the rabbit. IOP was measured using a Perkins tonometer. Intravenous administration of fluoxetine (6.0 mg kg-1) significantly increased IOP by 7.2 +/- 1.3 mmHg (P < 0.001). Fluoxetine administration also reduced the amount of urine excreted during the 24 hr, and increased the urine concentration of 5-hydroxyindole acetic acid (5-HIAA). Topical preadministration of ketanserin prevented a rise in IOP, without there being any effects on the other parameters examined. These findings indicate that intravenous administration of fluoxetine is able to raise IOP, through increased plasma levels of serotonin, which is confirmed by elevated 5-HIAA urine excretion and reduction in diuresis. Ketanserin, a specific 5-HT2A antagonist, counteracts the IOP increase brought about by fluoxetine, thus emphasizing the role of serotonin in the regulation of IOP and stressing the importance of including ophthalmological examination in the protocol of depressed patients undergoing SSRI therapy.
C Costagliola, and
L Mastropasqua, and
D Capone, and
M Verolino, and
M Ciancaglini, and
N Pisanti
January 1965,
Arquivos brasileiros de oftalmologia,
C Costagliola, and
L Mastropasqua, and
D Capone, and
M Verolino, and
M Ciancaglini, and
N Pisanti
July 2007,
European journal of pharmacology,
C Costagliola, and
L Mastropasqua, and
D Capone, and
M Verolino, and
M Ciancaglini, and
N Pisanti
January 1977,
Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft,
C Costagliola, and
L Mastropasqua, and
D Capone, and
M Verolino, and
M Ciancaglini, and
N Pisanti
March 1971,
Experimental eye research,
C Costagliola, and
L Mastropasqua, and
D Capone, and
M Verolino, and
M Ciancaglini, and
N Pisanti
July 1991,
Investigative ophthalmology & visual science,
C Costagliola, and
L Mastropasqua, and
D Capone, and
M Verolino, and
M Ciancaglini, and
N Pisanti
November 1999,
Investigative ophthalmology & visual science,
C Costagliola, and
L Mastropasqua, and
D Capone, and
M Verolino, and
M Ciancaglini, and
N Pisanti
February 1969,
American journal of optometry and archives of American Academy of Optometry,
C Costagliola, and
L Mastropasqua, and
D Capone, and
M Verolino, and
M Ciancaglini, and
N Pisanti
January 1987,
Journal of ocular pharmacology,
C Costagliola, and
L Mastropasqua, and
D Capone, and
M Verolino, and
M Ciancaglini, and
N Pisanti
January 1968,
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,
C Costagliola, and
L Mastropasqua, and
D Capone, and
M Verolino, and
M Ciancaglini, and
N Pisanti
January 1966,
Acta ophthalmologica,
