BIOMAT Database Logo BIOMAT Database Logo

Natural history of ampullary adenoma in familial adenomatous polyposis: reconfirmation of benign nature during extended surveillance. 2000

T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
Department of Endoscopic Diagnostics and Therapeutics, Kyushu University Hospital, Fukuoka, Japan.

OBJECTIVE Surgical or endoscopic papillectomy may be one of the therapeutic strategies for patients with familial adenomatous polyposis (FAP). To determine whether prophylactic papillectomy is necessary for FAP, we investigated the natural history of the ampullary adenoma in FAP. METHODS Eighteen subjects with FAP were surveyed by duodenoscopy with biopsy for >10 yr. Endoscopic appearance, histological findings, and immunohistochemical stainings for Ki-67 of ampulla were compared between initial and final endoscopic examinations. RESULTS The endoscopic grade in the ampulla remained unchanged in 16 subjects, whereas in two subjects an increase in the endoscopic grade was noted. In two subjects adenoma developed from an endoscopically and histologically normal ampulla. The histological grade of dysplasia increased in three of 12 subjects who initially had adenoma. The labeling index for Ki-67 was not different between initial and final examinations. CONCLUSIONS These data suggest that most ampullary adenoma of patients with FAP is static and that aggressive endoscopic or surgical removal is unnecessary for the adenoma.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011159 Population Surveillance Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy. Surveillance, Population
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D003138 Common Bile Duct Neoplasms Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
D004724 Endoscopy Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body. Endoscopic Surgical Procedures,Surgical Procedures, Endoscopic,Endoscopic Surgical Procedure,Endoscopy, Surgical,Surgical Endoscopy,Surgical Procedure, Endoscopic,Procedure, Endoscopic Surgical,Procedures, Endoscopic Surgical
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000236 Adenoma A benign epithelial tumor with a glandular organization. Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

Related Publications

T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
Surveillance of ampullary adenomas in familial adenomatous polyposis.
December 1994, Lancet (London, England),
T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
Duodenal adenoma surveillance in patients with familial adenomatous polyposis.
August 2015, World journal of gastrointestinal endoscopy,
T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
Natural history of ampullary adenomas in familial adenomatous polyposis: a long-term follow-up study.
March 2022, Gastrointestinal endoscopy,
T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
Endoscopic snare papillectomy in patients with familial adenomatous polyposis and ampullary adenoma.
September 1997, Endoscopy,
T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
The natural history of untreated duodenal and ampullary adenomas in patients with familial adenomatous polyposis followed in an endoscopic surveillance program.
March 1999, Gastrointestinal endoscopy,
T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
Familial adenomatous polyposis-associated ampullary adenoma: response to chemotherapy for concurrent metastatic adenocarcinoma.
June 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association,
T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
Natural history of colonic polyposis in young patients with familial adenomatous polyposis.
October 2018, Gastrointestinal endoscopy,
T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
Relapsing acute pancreatitis due to ampullary adenoma in a patient with familial adenomatous polyposis.
August 2006, Journal of gastroenterology,
T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
Endoscopic treatment of ampullary adenomas in familial adenomatous polyposis.
April 1996, Journal of clinical gastroenterology,
T Matsumoto, and M Iida, and S Nakamura, and K Hizawa, and T Yao, and M Tsuneyoshi, and M Fujishima
Attenuated familial adenomatous polyposis presenting as ampullary adenocarcinoma.
June 2003, Gut,
Copied contents to your clipboard!