The aim of the study was defining the antibiotic influence for endoscopic picture of the upper segment of gastrointestinal tract in Helicobacter pylori infection. We remained retrospectively analysis of 790 endoscopies. In 62 of the analysed patients we found Helicobacter pylori infection. We divided these children into two groups. The first group, contained 15 children, who received antibiotics for the previous year, for any reasons. The second, comparative group was made up of 47 children, who didn't receive antibiotics. We compared 18 characteristics of endoscopic picture in the oesophagus, stomach and duodenum mucosa. As a result of this study we conclude, that: 1) the most frequently the endoscopic changes were found in the stomach, as an erythema, an oedema and a nodularity of mucosa; 2) the inflammatory changes were in oesophagus and duodenum, as well; 3) we didn't observe the clear influence of antibiotics on the development of endoscopic changes in Helicobacter pylori infection; 4) in children, who didn't receive antibiotics, we observed polypus in the oesophagus, erosions in the stomach and ulcer in the duodenum. This may suggest the preventive role of antibiotics on intensity of gastrointestinal changes in Helicobacter pylori infected children.