Short-term fasting abolishes the sex-related difference in GH and leptin secretion in humans. 2000

M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Torino, 10126 Turin, Italy.

We studied growth hormone (GH) and leptin secretion in eight male (age 29.3 +/- 1.2 yr, body mass index 22.2 +/- 0.5 kg/m(2)) and seven female normal subjects (28.0 +/- 0.8 yr, 20.1 +/- 0.7 kg/m(2)) before and after 36 h of fasting. In the fed state, 8-h mean GH and leptin concentrations were higher in females (P < 0.05 and P < 0. 0001, respectively). Fasting increased GH and decreased leptin in both sexes. There was significant interaction between gender and fasting (P < 0.05 for GH and P < 0.005 for leptin). Females showed a slighter increase in GH but a more marked decrease in leptin, so that there was no significant gender-related difference in GH and leptin after fasting. Fasting did not modify insulin-like growth factor (IGF) I, IGF binding protein (IGFBP)-3, acid-labile subunit, or GH binding protein; increased IGFBP-1 and free fatty acids (P < 0.0001) but decreased glucose (P < 0.001) and insulin levels (P < 0.05). In males, insulin levels were higher (P < 0.05) in the fed state and underwent deeper reduction after fasting (interaction P < 0.03). In conclusion, GH and leptin secretions are higher in women than in men in the fed but not in the fasting condition, which abolishes these gender-related differences in humans.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007334 Insulin-Like Growth Factor I A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor. IGF-I,Somatomedin C,IGF-1,IGF-I-SmC,Insulin Like Growth Factor I,Insulin-Like Somatomedin Peptide I,Insulin Like Somatomedin Peptide I
D008297 Male Males
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D002352 Carrier Proteins Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes. Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D002940 Circadian Rhythm The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli. Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D004958 Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. 17 beta-Estradiol,Estradiol-17 beta,Oestradiol,17 beta-Oestradiol,Aerodiol,Delestrogen,Estrace,Estraderm TTS,Estradiol Anhydrous,Estradiol Hemihydrate,Estradiol Hemihydrate, (17 alpha)-Isomer,Estradiol Monohydrate,Estradiol Valerate,Estradiol Valeriante,Estradiol, (+-)-Isomer,Estradiol, (-)-Isomer,Estradiol, (16 alpha,17 alpha)-Isomer,Estradiol, (16 alpha,17 beta)-Isomer,Estradiol, (17-alpha)-Isomer,Estradiol, (8 alpha,17 beta)-(+-)-Isomer,Estradiol, (8 alpha,17 beta)-Isomer,Estradiol, (9 beta,17 alpha)-Isomer,Estradiol, (9 beta,17 beta)-Isomer,Estradiol, Monosodium Salt,Estradiol, Sodium Salt,Estradiol-17 alpha,Estradiol-17beta,Ovocyclin,Progynon-Depot,Progynova,Vivelle,17 beta Estradiol,17 beta Oestradiol,Estradiol 17 alpha,Estradiol 17 beta,Estradiol 17beta,Progynon Depot
D005215 Fasting Abstaining from FOOD. Hunger Strike,Hunger Strikes,Strike, Hunger,Strikes, Hunger
D005230 Fatty Acids, Nonesterified FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form. Fatty Acids, Free,Free Fatty Acid,Free Fatty Acids,NEFA,Acid, Free Fatty,Acids, Free Fatty,Acids, Nonesterified Fatty,Fatty Acid, Free,Nonesterified Fatty Acids
D005260 Female Females

Related Publications

M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
December 2001, The Journal of clinical endocrinology and metabolism,
M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
November 1998, Alcohol (Fayetteville, N.Y.),
M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
August 2001, The Journal of clinical endocrinology and metabolism,
M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
March 2006, The Journal of clinical endocrinology and metabolism,
M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
February 2022, Clinical diabetes and endocrinology,
M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
March 1997, Diabetologia,
M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
November 1996, Diabetes,
M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
August 2022, The Journal of clinical endocrinology and metabolism,
M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
November 1996, The Journal of clinical endocrinology and metabolism,
M Maccario, and G Aimaretti, and G Corneli, and C Gauna, and S Grottoli, and M Bidlingmaier, and C J Strasburger, and C Dieguez, and F F Casanueva, and E Ghigo
July 2008, The Journal of clinical endocrinology and metabolism,
Copied contents to your clipboard!