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4a alpha-Phorbol-9,9a-didecanoate, 4a alpha-phorbol-9-myristate-9a-acetate, and phorbol-9-myristate-9a-acetate-3-aldehyde were tested for skin tumor-promoting activity by using 7,12-dimethylbenz(a)anthracene as the initiating agent. There were 30 female ICR/Ha mice/group, and tests were continued for 434 to 461 days. 4a alpha-Phorbol-9,9a-didecanoate and 4a alpha-phorbol-9-myristate-9a-acetate were devoid of tumor-promoting activity. Phorbol-9-myristate-9a-acetate-3-aldehyde resulted in 10 mice with papillomas, 2 of which also bore squamous carcinomas of the skin. The positive control group, in which phorbol myristate acetate was used as promoting agent, resulted in 30 mice bearing multiple papillomas and 15 bearing squamous carcinomas of the skin. The effects of structural and stereochemical changes on tumor-promoting activity suggest that a primary interaction of the phorbol ester series is binding at specific sites on the plasma membrane.
B L Van Duuren, and
S S Tseng, and
A Segal, and
A C Smith, and
S Melchionne, and
I Seidman
April 1978,
Cancer research,
B L Van Duuren, and
S S Tseng, and
A Segal, and
A C Smith, and
S Melchionne, and
I Seidman
December 1976,
British journal of cancer,
B L Van Duuren, and
S S Tseng, and
A Segal, and
A C Smith, and
S Melchionne, and
I Seidman
July 1978,
International journal of cancer,
B L Van Duuren, and
S S Tseng, and
A Segal, and
A C Smith, and
S Melchionne, and
I Seidman
March 1978,
Cancer research,
B L Van Duuren, and
S S Tseng, and
A Segal, and
A C Smith, and
S Melchionne, and
I Seidman
August 1975,
Cancer research,
B L Van Duuren, and
S S Tseng, and
A Segal, and
A C Smith, and
S Melchionne, and
I Seidman
January 1983,
Microbiology and immunology,
B L Van Duuren, and
S S Tseng, and
A Segal, and
A C Smith, and
S Melchionne, and
I Seidman
September 1973,
Cancer research,
B L Van Duuren, and
S S Tseng, and
A Segal, and
A C Smith, and
S Melchionne, and
I Seidman
August 1971,
Cancer research,
B L Van Duuren, and
S S Tseng, and
A Segal, and
A C Smith, and
S Melchionne, and
I Seidman
January 1979,
Indian journal of experimental biology,
B L Van Duuren, and
S S Tseng, and
A Segal, and
A C Smith, and
S Melchionne, and
I Seidman
December 1974,
Cancer research,
