-transparent.png){kind=logo}
Transient increase of brain derived neurotrophic factor mRNA expression in substantia nigra reticulata after partial lesion of the nigrostriatal dopaminergic pathway. 2000
Laboratorio de Farmacología-Bioquímica, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago.
By using non-isostopic in situ hybridization we have demonstrated a transient increase of BDNF mRNA in the lateral subregion of the substantia nigra pars reticulata 1 week after intrastriatal application of 6-OH-DA. These changes correlate with a partial reduction of dopamine (DA) content in the striatum but with a normal tyrosine hydroxylase immunoreactivity in substantia nigra pars compacta. Our data suggest that non-DA, BDNF expressing cells in substantia nigra pars reticulata may play a role in neuronal protection after partial lesions of the DA nigrostriatal pathway.
Related Publications
E Aliaga, and
C Cárcamo, and
J Abarca, and
L Tapia-Arancibia, and
G Bustos
September 2007,
Neurotoxicity research,
E Aliaga, and
C Cárcamo, and
J Abarca, and
L Tapia-Arancibia, and
G Bustos
August 1999,
Brain research. Molecular brain research,
E Aliaga, and
C Cárcamo, and
J Abarca, and
L Tapia-Arancibia, and
G Bustos
February 1999,
Neuroreport,
E Aliaga, and
C Cárcamo, and
J Abarca, and
L Tapia-Arancibia, and
G Bustos
February 1996,
Brain research,
E Aliaga, and
C Cárcamo, and
J Abarca, and
L Tapia-Arancibia, and
G Bustos
May 1980,
Nature,
E Aliaga, and
C Cárcamo, and
J Abarca, and
L Tapia-Arancibia, and
G Bustos
February 2013,
Neural regeneration research,
E Aliaga, and
C Cárcamo, and
J Abarca, and
L Tapia-Arancibia, and
G Bustos
July 1992,
Neuroscience letters,
E Aliaga, and
C Cárcamo, and
J Abarca, and
L Tapia-Arancibia, and
G Bustos
March 1991,
Nature,
E Aliaga, and
C Cárcamo, and
J Abarca, and
L Tapia-Arancibia, and
G Bustos
April 1998,
Neurochemical research,
E Aliaga, and
C Cárcamo, and
J Abarca, and
L Tapia-Arancibia, and
G Bustos
April 1998,
Neuroscience research,
