-transparent.png){kind=logo}
Prophylactic effect of repeated intravenous administrations of oil-attached BCG cell-wall skeleton (BCG-CWS) on the induction of tumor by 7,12-dimethylbenz[a]anthracene (DMBA) was investigated in various strains of mice. The subcutaneous injection of DMBA emulsified in oil induced squamous cell carcinoma in almost all of the strains of mice. Treatment of C57BL/6, BALB/c, and ddO strains with BCG-CWS with appropriate route and timing resulted in the retardation of DMBA-induced tumor development manifested by a prolonged latent period of tumor outgrowth. In contrast, the same BCG-CWS treatment of C3H/He and BTK mice was incapable in preventing such DMBA-induced carcinogenesis. Thus, the treatment with BCG-CWS was effective for preventing the DMBA-induced carcinogenesis in certain strains of mice, but the effectiveness varied depending on the strain. The implication of such a strain variationof the BCG-CWS effect on the prophylaxis of chemical carcinogenesis was discussed in the context of differences in the magnitude of immunopotentiation of the host by BCG-CWS.
R Ikegami, and
K Takatsu, and
S Ono, and
T Hamaoka, and
H Fujiwara, and
M Kitagawa, and
I Azuma, and
Y Yamamura
October 1982,
Gan,
R Ikegami, and
K Takatsu, and
S Ono, and
T Hamaoka, and
H Fujiwara, and
M Kitagawa, and
I Azuma, and
Y Yamamura
February 1984,
European journal of cancer & clinical oncology,
R Ikegami, and
K Takatsu, and
S Ono, and
T Hamaoka, and
H Fujiwara, and
M Kitagawa, and
I Azuma, and
Y Yamamura
January 1982,
Carcinogenesis,
R Ikegami, and
K Takatsu, and
S Ono, and
T Hamaoka, and
H Fujiwara, and
M Kitagawa, and
I Azuma, and
Y Yamamura
January 1988,
Cancer research,
R Ikegami, and
K Takatsu, and
S Ono, and
T Hamaoka, and
H Fujiwara, and
M Kitagawa, and
I Azuma, and
Y Yamamura
September 1969,
Mie medical journal,
R Ikegami, and
K Takatsu, and
S Ono, and
T Hamaoka, and
H Fujiwara, and
M Kitagawa, and
I Azuma, and
Y Yamamura
June 1972,
Journal of the National Cancer Institute,
R Ikegami, and
K Takatsu, and
S Ono, and
T Hamaoka, and
H Fujiwara, and
M Kitagawa, and
I Azuma, and
Y Yamamura
June 1969,
Nature,
R Ikegami, and
K Takatsu, and
S Ono, and
T Hamaoka, and
H Fujiwara, and
M Kitagawa, and
I Azuma, and
Y Yamamura
July 1975,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
R Ikegami, and
K Takatsu, and
S Ono, and
T Hamaoka, and
H Fujiwara, and
M Kitagawa, and
I Azuma, and
Y Yamamura
January 1971,
Tumori,
R Ikegami, and
K Takatsu, and
S Ono, and
T Hamaoka, and
H Fujiwara, and
M Kitagawa, and
I Azuma, and
Y Yamamura
August 1999,
Mutation research,
