Biomaterial Database

Prophylactic chemotherapy with low-dosage trimethoprim-sulfamethoxazole following acute urinary tract infections in children. 1975

N Sher

The cases of 10 children with acute and recurrent infection of the urinary tract are presented. Their ages were between 7 weeks and 9 years. Five of the children had been previously treated with a combination of sulfisoxazole, ampicillin, mandelamine and nitrofurantion and four of these children had "breakthrough" infections. When trimethoprim-sulfamethoxazole was administered twice weekly no further infections were noted in four of these five patients. The second group of five children were started on trimethoprim-sulfamethoxazole from the start of their infection and treatment was continued twice weekly for 5 to 7 months. No recurrence of infection of the urine has been detected up to the present time. It is concluded that treatment with trimethoprim-sulfamethoxazole initiated at the outset of urinary tract infection and twice weekly is a valuable drug in children, provided the organism responsible for the infection is sensitive to this agent.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D008709	Methenamine	An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173)	Hexamethylenetetramine,Hexamine,Aminoform,Hexamine Silver,Methenamine Silver,Silver Methenamine,Urotropin,Methenamine, Silver,Silver, Hexamine,Silver, Methenamine
D009582	Nitrofurantoin	A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.	Furadantin,Furadantine,Furadoine,Furadonine,Furantoin,Macrodantin,Nitrofurantoin Sodium Salt,Nitrofurantoin, Monohydrate
D011512	Proteus Infections	Infections with bacteria of the genus PROTEUS.	Infections, Proteus,Infection, Proteus,Proteus Infection
D012008	Recurrence	The return of a sign, symptom, or disease after a remission.	Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D004927	Escherichia coli Infections	Infections with bacteria of the species ESCHERICHIA COLI.	E coli Infections,E. coli Infection,Infections, E coli,Infections, Escherichia coli,E coli Infection,E. coli Infections,Escherichia coli Infection,Infection, E coli,Infection, E. coli,Infection, Escherichia coli